Di Maria Alessandra, Ferraro Vanessa, Barone Gianmaria, Gaeta Alessandro, Vinciguerra Paolo, Confalonieri Filippo
Department of Ophthalmology, IRCCS Humanitas Research Hospital, Rozzano, Milan, 20089, Italy.
Department of Internal Medicine and Medical Specialties (DIMI), Università di Genova, Viale Benedetto XV, Genova, 16132, Italy.
Graefes Arch Clin Exp Ophthalmol. 2025 Jan;263(1):141-146. doi: 10.1007/s00417-024-06589-5. Epub 2024 Jul 29.
The purpose of this study is to assess the variations in anterior chamber depth (ACD), axial length (AXL), and intraocular pressure (IOP) in both phakic and pseudophakic eyes undergoing preoperative intravenous mannitol infusion. The study was conducted at the Ophthalmology Department of IRCSS Humanitas in Milan, Italy. This is a prospective and non-randomized study.
40 patients with phakic eyes and 40 patients with pseudophakic eyes scheduled for cataract surgery in their fellow eye were included. Prior to the surgery, comprehensive ophthalmic examinations were conducted, including IOP measurement, and bilateral biometry performed with Anterion (Heidelberg Engineering GmbH, 69,115, Heidelberg, Germany). All patients received intravenous infusion of mannitol before the surgery. One hour after cataract extraction, the patients underwent the same set of examinations. We analyzed the changes AXL, ACD and IOP in the eye opposite to the one that underwent surgery.
The comparison between preoperative and postoperative parameters showed no differences in AXL (p = 0.34 and p = 0.53) and in ACD (p = 0.38 and p = 0.31) in the phakic and in the pseudophakic group, respectively. Instead, a statistically significant difference was found between the mean preoperative and postoperative IOP (p = 0.02) for the phakic group and (p = 0.03) for the pseudophakic group.
The administration of mannitol does not lead to any changes in the ACD and AXL, regardless of whether the eyes are phakic or pseudophakic. However, there is a statistically significant reduction in IOP. Nonetheless, it is important to consider the various side effects associated with mannitol infusion.
本研究的目的是评估术前静脉输注甘露醇的有晶状体眼和人工晶状体眼的前房深度（ACD）、眼轴长度（AXL）和眼压（IOP）的变化。该研究在意大利米兰IRCSS Humanitas眼科进行。这是一项前瞻性非随机研究。
纳入40例计划对另一只眼进行白内障手术的有晶状体眼患者和40例人工晶状体眼患者。手术前，进行了全面的眼科检查，包括眼压测量，并用Anterion（德国海德堡工程有限公司，海德堡69,115）进行了双眼生物测量。所有患者在手术前接受静脉输注甘露醇。白内障摘除术后1小时，患者接受相同的一组检查。我们分析了手术眼对侧眼的AXL、ACD和IOP的变化。
术前和术后参数比较显示，有晶状体组和人工晶状体组的AXL（p = 0.34和p = 0.53）和ACD（p = 0.38和p = 0.31）均无差异。相反，有晶状体组术前和术后平均眼压之间存在统计学显著差异（p = 0.02），人工晶状体组为（p = 0.03）。
无论眼睛是有晶状体还是人工晶状体，输注甘露醇均不会导致ACD和AXL发生任何变化。然而，眼压有统计学显著降低。尽管如此，考虑与甘露醇输注相关的各种副作用很重要。
