细胞溶质内递送细胞色素缀合物通过 caspase-3 依赖性途径在纳摩尔水平诱导细胞凋亡。
Cytosolic delivery of cytochrome conjugates induces apoptosis at nanomolar levels through a caspase-3-dependent pathway.
机构信息
School of Biology, Food, and Environment, Hefei University, Hefei, Anhui 230601, China.
Key Laboratory of Precision and Intelligent Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
出版信息
Chem Commun (Camb). 2024 Aug 13;60(66):8764-8767. doi: 10.1039/d4cc02371d.
Cytochrome (CytC) is conjugated with a small molecule TG6 to give TG6-CytC, which is directly delivered into cytosol, triggering the release of endogenous CytC from mitochondria, and inducing a caspase-3-dependent apoptosis with an IC down to 2.4 nM. This work shows an efficient strategy for intracellular protein delivery.
细胞色素 C (CytC) 与小分子 TG6 缀合得到 TG6-CytC，它可直接递送至细胞质，从线粒体中引发内源性 CytC 的释放，并诱导依赖半胱天冬酶-3 的细胞凋亡，IC 低至 2.4 nM。这项工作展示了一种有效的细胞内蛋白质递呈策略。
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