高剂量、双盲法研究赛鲁肽治疗精神分裂症的疗效。

A high-dose, double-blind study of ceruletide in the treatment of schizophrenia.

作者信息

Mattes J A, Hom W, Rochford J M

出版信息

Am J Psychiatry. 1985 Dec;142(12):1482-4. doi: 10.1176/ajp.142.12.1482.

DOI:10.1176/ajp.142.12.1482

Abstract

Ceruletide, a cholecystokinin analogue, has been reported to interact with dopamine in the CNS and to benefit schizophrenic individuals. The authors, using a double-blind design, a higher total dose, and a larger sample size than previous studies, found no evidence of benefit.

摘要

雨蛙肽是一种缩胆囊素类似物，据报道它可在中枢神经系统中与多巴胺相互作用，并对精神分裂症患者有益。作者采用了双盲设计，使用了比以往研究更高的总剂量和更大的样本量，但未发现有益的证据。