Mei Jenny Y, Hauspurg Alisse, Corry-Saavedra Kate, Nguyen Tina A, Murphy Aisling, Miller Emily S
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA (Mei, Corry-Saavedra, Nguyen, and Murphy).
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Pittsburgh Medical Center Magee-Womens Hospital, Pittsburgh, PA (Hauspurg).
Am J Obstet Gynecol MFM. 2024 Sep;6(9):101442. doi: 10.1016/j.ajogmf.2024.101442. Epub 2024 Jul 27.
Recognizing the importance of close follow-up after hypertensive disorders of pregnancy, many centers have initiated programs to support postpartum remote blood pressure management.
This study aimed to evaluate the cost-effectiveness of remote blood pressure management to determine the scalability of these programmatic interventions.
This was a cost-effectiveness analysis of using remote blood pressure management vs usual care to manage postpartum hypertension. The modeled remote blood pressure management included provision of a home blood pressure monitor, guidance on warning symptoms, instructions on blood pressure self-monitoring twice daily, and clinical staff to manage population-level blood pressures as appropriate. Usual care was defined as guidance on warning symptoms and recommendations for 1 outpatient visit for blood pressure monitoring within a week after discharge. This study designed a Markov model that ran over fourteen 1-day cycles to reflect the initial 2 weeks after delivery when most emergency department visits and readmissions occur and remote blood pressure management is clinically anticipated to be most impactful. Parameter values for the base-case scenario were derived from both internal data and literature review. Quality-adjusted life-years were calculated over the first year after delivery and reflected the short-term morbidities associated with hypertensive disorders of pregnancy that, for most birthing people, resolve by 2 weeks after delivery. Sensitivity analyses were performed to assess the strength and validity of the model. The primary outcome was the incremental cost-effectiveness ratio, which was defined as the cost needed to gain 1 quality-adjusted life-year. The secondary outcome was incremental cost per readmission averted. Analyses were performed from a societal perspective.
In the base-case scenario, remote blood pressure management was the dominant strategy (ie, cost less, higher quality-adjusted life-years). In univariate sensitivity analyses, the most cost-effective strategy shifted to usual care when the cost of readmission fell below $2987.92 and the rate of reported severe range blood pressure with a response in remote blood pressure management was <1%. Assuming a willingness to pay of $100,000 per quality-adjusted life-year, using remote blood pressure management was cost-effective in 99.28% of simulations in a Monte Carlo analysis. Using readmissions averted as a secondary effectiveness outcome, the incremental cost per readmission averted was $145.00.
Remote blood pressure management for postpartum hypertension is cost saving and has better outcomes than usual care. Our data can be used to inform future dissemination of and support funding for remote blood pressure management programs.
认识到妊娠高血压疾病产后密切随访的重要性,许多中心已启动项目以支持产后远程血压管理。
本研究旨在评估远程血压管理的成本效益,以确定这些项目干预措施的可扩展性。
这是一项使用远程血压管理与常规护理来管理产后高血压的成本效益分析。模拟的远程血压管理包括提供家庭血压监测仪、关于警示症状的指导、每日两次血压自我监测的说明,以及临床工作人员在适当时管理人群水平的血压。常规护理定义为关于警示症状的指导以及出院后一周内进行1次门诊血压监测的建议。本研究设计了一个马尔可夫模型,该模型运行14个1天周期,以反映分娩后的最初2周,此时大多数急诊就诊和再入院情况发生,并且预计远程血压管理在临床上最具影响力。基础病例情景的参数值来自内部数据和文献综述。在分娩后的第一年计算质量调整生命年,并反映与妊娠高血压疾病相关的短期发病率,对于大多数产妇来说,这些发病率在分娩后2周内会缓解。进行敏感性分析以评估模型的强度和有效性。主要结局是增量成本效益比,定义为获得1个质量调整生命年所需的成本。次要结局是避免每次再入院的增量成本。分析是从社会角度进行的。
在基础病例情景中,远程血压管理是主导策略(即成本更低,质量调整生命年更高)。在单变量敏感性分析中,当再入院成本降至2987.92美元以下且远程血压管理中报告的严重范围血压且有反应的发生率<1%时,最具成本效益的策略转变为常规护理。假设每个质量调整生命年的支付意愿为100,000美元,在蒙特卡洛分析中,99.28%的模拟中使用远程血压管理具有成本效益。将避免再入院作为次要有效性结局,避免每次再入院的增量成本为145.00美元。
产后高血压的远程血压管理具有成本节约且比常规护理有更好的结局。我们的数据可用于为未来远程血压管理项目的推广和支持资金提供信息。