揭示 MMP9 的双向作用：肾脏损伤中的关键角色。

Unveiling the bidirectional role of MMP9: A key player in kidney injury.

机构信息

Anhui University of Traditional Chinese Medicine, Hefei 230000, People's Republic of China; Institute of Innovative Medicine, Biocytogen Pharmaceuticals (Beijing) Co, Ltd., Beijing 102609, People's Republic of China; Joint Graduate School, Yangtze Delta Drug Advanced Research Institute, Nantong 226133, People's Republic of China.

Anhui University of Traditional Chinese Medicine, Hefei 230000, People's Republic of China; Department of Pharmacology, Biocytogen Pharmaceuticals (Beijing) Co, Ltd, Beijing 102609, People's Republic of China; Joint Graduate School, Yangtze Delta Drug Advanced Research Institute, Nantong 226133, People's Republic of China.

出版信息

Cell Signal. 2024 Oct;122:111312. doi: 10.1016/j.cellsig.2024.111312. Epub 2024 Jul 27.

DOI:10.1016/j.cellsig.2024.111312

PMID:39074714

Abstract

Matrix metalloproteinases (MMPs) are a group of zinc-dependent proteolytic metalloenzymes that are involved in numerous pathological conditions, including nephropathy. MMP9, a member of the MMPs family, is categorized as a constituent of the gelatinase B subgroup, and its involvement in extracellular matrix (ECM) remodeling and renal fibrosis highlights its importance in the development and progression of renal diseases. The exact role of MMP9 in the development of kidney diseases is still controversial. This study investigated the dual role of MMP9 in kidney injury, discussing its implications in the pathogenesis of kidney diseases and investigating the design and mechanism of MMP9 inhibitors based on previous studies. This study provides an effective basis for the development of novel and selective MMP9 inhibitors for treating renal diseases.

摘要

基质金属蛋白酶（MMPs）是一组锌依赖性蛋白水解金属酶，参与多种病理状况，包括肾病。MMP9 是 MMPs 家族的成员之一，被归类为明胶酶 B 亚群的组成部分，其在细胞外基质（ECM）重塑和肾纤维化中的作用突出了其在肾脏疾病发展和进展中的重要性。MMP9 在肾脏疾病发展中的确切作用仍存在争议。本研究探讨了 MMP9 在肾脏损伤中的双重作用，讨论了其在肾脏疾病发病机制中的意义，并基于先前的研究探讨了 MMP9 抑制剂的设计和机制。本研究为开发用于治疗肾脏疾病的新型和选择性 MMP9 抑制剂提供了有效的基础。