Clinical Haematology, Alfred Hospital and Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia.
Department of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Intern Med J. 2024 Sep;54(9):1548-1556. doi: 10.1111/imj.16453. Epub 2024 Jul 30.
Sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication which can develop after haemopoietic stem cell transplantation (HSCT) and some antibody-drug conjugates. Several SOS/VOD diagnostic and management guidelines exist, with the most recent and refined being the European Society for Blood and Marrow Transplantation adult and paediatric guidelines. Timely diagnosis and effective management (including the availability of therapeutic options) significantly contribute to improved patient outcomes. In Australia and New Zealand, there is variability in clinical practice and access to SOS/VOD therapies. This review aims to summarise the current evidence for SOS/VOD diagnosis, prevention and treatment and to provide recommendations for SOS/VOD in the context of contemporary Australasian HSCT clinical practice.
窦状隙阻塞综合征/肝小静脉闭塞病（SOS/VOD）是造血干细胞移植（HSCT）和某些抗体药物偶联物后可能发生的危及生命的并发症。目前存在几种 SOS/VOD 诊断和管理指南，其中最新和最完善的是欧洲血液和骨髓移植学会成人和儿科指南。及时诊断和有效管理（包括治疗方案的可用性）显著有助于改善患者结局。在澳大利亚和新西兰，SOS/VOD 的临床实践和治疗方法存在差异。本综述旨在总结 SOS/VOD 的诊断、预防和治疗的现有证据，并就当代澳大拉西亚 HSCT 临床实践中的 SOS/VOD 提供建议。
