Hammersen F, Hammersen E
Basic Res Cardiol. 1985 Sep-Oct;80(5):491-501. doi: 10.1007/BF01907913.
Contrary to our former belief, endothelial cells can no longer be classified as a homogeneous cell population which, as a living border layer between the blood and the extravascular space, serves exclusively as a selective filter. The technique of routinely culturing endothelial cells from various sources has provided new insights into an unexpected multitude of synthetic and metabolic capacities of these cells, such as the degradation of arachidonic acid, the enzymatic activation of angiotensin I, and many others. However, many of these results are still contradictory, and therefore make any critical review of the data almost impossible. Some examples for this are briefly outlined in this contribution. Irrespective of this, these new results have to be taken into account, although the possibly high specificity of the endothelium will render the interpretation of future data, particularly those obtained from animal models, much more difficult. However, a simple neglect of these complexities would be disastrous for all future endothelial research.
与我们之前的认知相反，内皮细胞不再能被归类为单一的细胞群体，作为血液与血管外空间之间的活性边界层，它不再仅仅充当选择性过滤器。从各种来源常规培养内皮细胞的技术为这些细胞意想不到的多种合成和代谢能力提供了新的见解，比如花生四烯酸的降解、血管紧张素I的酶促激活等等。然而，许多这些结果仍然相互矛盾，因此几乎不可能对数据进行任何批判性审查。本论文简要概述了一些这样的例子。尽管如此，这些新结果必须被考虑在内，尽管内皮细胞可能具有高度特异性，这将使未来数据的解读，尤其是从动物模型获得的数据的解读变得更加困难。然而，简单地忽略这些复杂性对所有未来的内皮研究来说将是灾难性的。
