Wang Yu-Pei, Wei Hui-Xia, Hu Yuan-Yuan, Niu Yu-Ming
Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People's Republic of China.
Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People's Republic of China.
Nat Sci Sleep. 2024 Jul 23;16:1045-1052. doi: 10.2147/NSS.S476277. eCollection 2024.
This study was conducted to investigate the bidirectional causal relationship between obstructive sleep apnea (OSA) and temporomandibular disorders (TMD).
Using an online pooled dataset of genome-wide association studies (GWAS), a two-sample bi-directional Mendelian randomization (MR) method was implemented. Inverse variance weighting was used as the primary analyses approach, and other methods of MR Egger, weighted median method, MR-Egger, Simple mode, and Weighted mode analysis were conducted as supplements to evaluate the causal relationship between OSA and TMD with odds ratios (OR) and 95% confidence interval (CI). Furthermore, the Cochran Q, MR-Egger, and MR-PRESSO approaches were used to perform the heterogeneity test and multiple validity.
The general results of the forward MR analysis indicated that OSA had a significant causal influence on TMD (OR=1.241, 95% CI: 1.009-1.526, P=0.041), but no significant correlation was observed in the reverse MR analysis (IVW: OR=0.975, 95% CI=0.918-1.036, P=0.411).
In summary, our research demonstrated a hereditary causative relationship between OSA and TMD, indicating that appropriate intervention is required for both prevention and treatment of TMD.
本研究旨在探讨阻塞性睡眠呼吸暂停（OSA）与颞下颌关节紊乱病（TMD）之间的双向因果关系。
使用全基因组关联研究（GWAS）的在线汇总数据集，采用两样本双向孟德尔随机化（MR）方法。以逆方差加权作为主要分析方法，并采用MR-Egger、加权中位数法、MR-Egger、简单模式和加权模式分析等其他方法作为补充，以比值比（OR）和95%置信区间（CI）评估OSA与TMD之间的因果关系。此外，采用Cochran Q、MR-Egger和MR-PRESSO方法进行异质性检验和多重有效性分析。
正向MR分析的总体结果表明，OSA对TMD有显著的因果影响（OR=1.241，95%CI：1.009-1.526，P=0.041），但反向MR分析未观察到显著相关性（IVW：OR=0.975，95%CI=0.918-1.036，P=0.411）。
总之，我们的研究证明了OSA与TMD之间存在遗传因果关系，表明在TMD的预防和治疗中都需要进行适当干预。
