Wu Xiaolin, Wu Qiaolan, Gao Lin, Lv Yu, Wu Zhichun
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, 250355 Jinan, Shandong, China.
Shandong Co-Innovation Center of Classic TCM Formula, Shandong Provincial Education Department, 250355 Jinan, Shandong, China.
Rev Cardiovasc Med. 2024 Mar 28;25(4):121. doi: 10.31083/j.rcm2504121. eCollection 2024 Apr.
Following long-term hypertension, mechanical stretching and neuroendocrine stimulation, cause multiple heterogeneous cells of the heart to interact, and result in myocardial remodeling with myocardial hypertrophy and fibrosis. The immune system, specifically macrophages, plays a vital role in this process. Macrophages are heterogeneous and plastic. Regulated by factors such as microenvironment and cytokines, polarization can be divided into two main forms: M1/M2, with different polarizations playing different roles in left ventricular structural remodeling associated with hypertension. However, descriptions of macrophage phenotypes in hypertension-induced myocardial hypertrophy models are not completely consistent. This article summarizes the phenotypes of macrophages in several models, aiming to assist researchers in studying macrophage phenotypes in hypertension-induced left ventricular structural remodeling models.
长期高血压、机械牵张和神经内分泌刺激会导致心脏多种异质性细胞相互作用，进而引发心肌重塑，出现心肌肥厚和纤维化。免疫系统，尤其是巨噬细胞，在这一过程中起着至关重要的作用。巨噬细胞具有异质性和可塑性。在微环境和细胞因子等因素的调控下，其极化可分为两种主要形式：M1/M2，不同的极化形式在高血压相关的左心室结构重塑中发挥着不同作用。然而，高血压诱导的心肌肥厚模型中巨噬细胞表型的描述并不完全一致。本文总结了几种模型中巨噬细胞的表型，旨在帮助研究人员研究高血压诱导的左心室结构重塑模型中的巨噬细胞表型。
