cGAS-STING通路在心血管系统中的作用及机制
Role and Mechanism of cGAS-STING Pathway in Cardiovascular System.
作者信息
Yu Xianqiang, Pan Silin
机构信息
Heart Center, Women and Children's Hospital Affiliated to Qingdao University, 266034 Qingdao, Shandong, China.
出版信息
Rev Cardiovasc Med. 2024 Apr 7;25(4):135. doi: 10.31083/j.rcm2504135. eCollection 2024 Apr.
The cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway is a part of the innate immune system that plays a role in the cardiovascular system. It acts as a surveillance system, detecting and responding to cytosolic DNA, viral DNA, and other intracellular DNA species. Activation of the cGAS-STING pathway leads to the production of inflammatory cytokines and type I interferons, which are involved in the immune response. In the cardiovascular system, the cGAS-STING pathway has been implicated in various physiological and pathological processes. It contributes to vascular inflammation, atherosclerosis, endothelial dysfunction and cardiac remodeling and heart failure. In this review, we will elaborate on the research progress of the role of cGAS-STING in cardiovascular system.
环磷酸鸟苷-磷酸腺苷（GMP-AMP）合酶（cGAS）-干扰素基因刺激因子（STING）通路是先天性免疫系统的一部分，在心血管系统中发挥作用。它作为一个监测系统，检测并响应胞质DNA、病毒DNA和其他细胞内DNA种类。cGAS-STING通路的激活会导致炎性细胞因子和I型干扰素的产生，这些因子参与免疫反应。在心血管系统中，cGAS-STING通路涉及多种生理和病理过程。它会导致血管炎症、动脉粥样硬化、内皮功能障碍以及心脏重塑和心力衰竭。在本综述中，我们将详细阐述cGAS-STING在心血管系统中作用的研究进展。
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