骨髓瘤患者尿中假尿嘧啶核苷排泄情况
Urinary pseudouridine excretion in myelomatosis.
作者信息
Sørensen S H, Brown D A, Cooper E H, Kelly K A, MacLennan I C
出版信息
Br J Cancer. 1985 Dec;52(6):863-6. doi: 10.1038/bjc.1985.270.
Urinary psi excretion is independent of the main indices of tumour activity in myelomatosis (serum paraprotein, serum beta 2-microglobulin, serum creatinine and urinary light chain production). The mean (+/- s.d.) psi at presentation was 40.7 +/- 22.6 nmol. mumol ucr-1, compared to 25.4 +/- 4.8 nmol. mumol ucr-1 in controls. Urinary psi levels at presentation are significantly related to prognosis, the higher the level the poorer the prognosis. However, when these levels have been stratified according to the corresponding level of serum beta 2m, the level adds little as a prognostic factor.
尿中ψ排泄与骨髓瘤（血清副蛋白、血清β2-微球蛋白、血清肌酐和尿轻链产生）肿瘤活性的主要指标无关。初诊时ψ的平均值（±标准差）为40.7±22.6 nmol·μmol尿肌酐-1，而对照组为25.4±4.8 nmol·μmol尿肌酐-1。初诊时尿ψ水平与预后显著相关，水平越高预后越差。然而，当根据血清β2m的相应水平进行分层时，该水平作为预后因素的作用不大。
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