[蛋白质合成装置不同功能状态下大鼠肝细胞中18S - rRNA的代谢]
[Metabolism of 18S-rRNA in rat liver cells in different functional states of the protein-synthesizing apparatus].
作者信息
Chirkov G P, Druzhinina M K, Todorov I N
出版信息
Biokhimiia. 1985 Oct;50(10):1587-90.
PMID:3907722
Abstract
The ratio of absolute radioactivities of 28S and 18S ribosomal RNA in membrane-bound and free polysomes and in free ribosomes of rat liver were studied under conditions of translation inhibition by cycloheximide, insulin and cAMP. Insulin and cAMP, in contrast with cycloheximide, did not induce selective degradation of 18S-rRNA. The data obtained are discussed in terms of the feasible role of S6 protein phosphorylation in degradation of the 40S ribosomal subunit.
摘要
在环己酰亚胺、胰岛素和环磷酸腺苷（cAMP）抑制翻译的条件下，研究了大鼠肝脏膜结合多核糖体和游离多核糖体以及游离核糖体中28S和18S核糖体RNA的绝对放射性比率。与环己酰亚胺不同，胰岛素和cAMP不会诱导18S - rRNA的选择性降解。根据S6蛋白磷酸化在40S核糖体亚基降解中的可能作用对所得数据进行了讨论。
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