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以氰胺为原料绿色高效合成二苄基氰胺和脲。

Green and efficient synthesis of dibenzyl cyanamides and ureas with cyanamide as a block.

作者信息

Wang Zhongjie, He Yu, Wang Fang, Wang Yan, Luo Hui, Wu Jianglong, Yang Jinhui

机构信息

State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering, School of Chemistry and Chemical Engineering, Ningxia University Yinchuan 750021 China

School of Chemistry and Chemical Engineering, Ningxia Normal University Guyuan 756000 China

出版信息

RSC Adv. 2024 Jul 29;14(33):23693-23698. doi: 10.1039/d4ra04286g. eCollection 2024 Jul 26.

DOI:10.1039/d4ra04286g
PMID:39077314
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11284761/
Abstract

A method for the two-step synthesis of dibenzyl cyanamide and dibenzyl urea cyanamide is presented. This approach is both efficient and environmentally friendly. Various ,-dibenzyl ureas could be obtained by reactions of ,-dibenzyl cyanamides and ,-dibenzyl cyanamides as intermediates formed from cyanamide. In the absence of metal, ligand and hydrogen peroxide as the oxidant, products with moderate yields have been obtained under mild conditions. Key features include the use of widely available and easily handled cyanamide sources as starting materials.

摘要

介绍了一种两步合成二苄基氰胺和二苄基脲氰胺的方法。该方法既高效又环保。通过氰胺形成的中间体二苄基氰胺和二苄基氰胺反应，可以得到各种二苄基脲。在没有金属、配体和作为氧化剂的过氧化氢的情况下，在温和条件下获得了中等产率的产物。关键特征包括使用广泛可得且易于处理的氰胺源作为起始原料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/a05e291c3fdf/d4ra04286g-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/ff3162e6dcf8/d4ra04286g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/8ffc72fbf62b/d4ra04286g-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/f43338fa6554/d4ra04286g-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/62dbf1fe5d9f/d4ra04286g-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/0b772c6195c3/d4ra04286g-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/a05e291c3fdf/d4ra04286g-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/ff3162e6dcf8/d4ra04286g-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/8ffc72fbf62b/d4ra04286g-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/f43338fa6554/d4ra04286g-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/62dbf1fe5d9f/d4ra04286g-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/0b772c6195c3/d4ra04286g-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9d1/11284761/a05e291c3fdf/d4ra04286g-s6.jpg

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