Athaillah Farida, Hambal Muhammad, Vanda Heni, Frengki Frengki, Sari Wahyu Eka
Department of Parasitology, Faculty of Medicine Veterinary, Syiah Kuala University, Banda Aceh, Indonesia.
Department of Pharmacology, Faculty of Medicine Veterinary, Syiah Kuala University, Banda Aceh, Indonesia.
Vet World. 2024 Jun;17(6):1336-1347. doi: 10.14202/vetworld.2024.1336-1347. Epub 2024 Jun 21.
The potential of plants as anthelmintics is very large, but there is still very little research conducted in the search for effective, safe, easily obtained, and affordable anthelmintic candidates. Palem putri () is an ornamental plant that is interesting to study because it is included in the areca nut group which is reported to have strong abilities as anthelmintics. The study aims to evaluate the anthelmintic efficacy of against trematode worms such as spp. and .
This research employs both and computational techniques. An anthelmintic test was carried out on spp. worms at concentrations of 10%, 25%, and 40% (gr/v), assessing mortality index as the observable outcome, followed by a histopathological investigation of the deceased worms for tissue and cellular damage evaluation. Seventeen compounds from seeds were studied for their anthelmintic activity against worms using the quantitative structure-activity relationship technique, molecular docking, and Lipinski's rule analysis for orally administered medication.
About 25% and 40% extracts of damaged the tegument organs in the worms. Seventeen compounds in seed extract, on average, yielded a higher anthelmintic index on than praziquantel. Eleven of the 17 compounds exhibit stronger affinity than praziquantel, with routine and gallic acid being the top two ligands (∆Gbinding values: -11.65 kcal/mol and -11.07 kcal/mol, respectively). According to Lipinski's rule analysis, only routine compounds cannot be orally administered.
The seeds of have potential as an anthelmintic agent for spp. at concentrations of 25%-40% (gr/v).
植物作为驱虫剂的潜力巨大，但在寻找有效、安全、易于获取且价格合理的驱虫候选物方面，开展的研究仍非常少。白槟榔（）是一种具有研究价值的观赏植物，因为它属于槟榔属，据报道该属具有很强的驱虫能力。本研究旨在评估其对吸虫类蠕虫如 属和 属蠕虫的驱虫效果。
本研究采用实验和计算技术。对 属蠕虫进行了浓度为10%、25%和40%（克/体积）的驱虫试验，以死亡率指数作为可观察结果，随后对死亡蠕虫进行组织病理学调查，以评估组织和细胞损伤情况。利用定量构效关系技术、分子对接以及针对口服药物的Lipinski规则分析，研究了白槟榔种子中的17种化合物对 蠕虫的驱虫活性。
约25%和40%的白槟榔提取物破坏了蠕虫的体表器官。白槟榔种子提取物中的17种化合物，平均而言，对 的驱虫指数高于吡喹酮。17种化合物中有11种表现出比吡喹酮更强的亲和力，其中芦丁和没食子酸是亲和力最强的两种配体（结合自由能值分别为-11.65千卡/摩尔和-11.07千卡/摩尔）。根据Lipinski规则分析，只有芦丁化合物不能口服给药。
白槟榔种子在浓度为25%-40%（克/体积）时，具有作为 属蠕虫驱虫剂的潜力。
