Hao Yan, Liu Wei
Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, 150001 Harbin, Heilongjiang, China.
Department of Geriatric Cardiovascular Division, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510080 Guangzhou, Guangdong, China.
Rev Cardiovasc Med. 2023 Mar 6;24(3):82. doi: 10.31083/j.rcm2403082. eCollection 2023 Mar.
Cardiac aging is a natural process accompanied by cardiomyocyte hypertrophy and dysfunction. These changes can lead to adverse organ remodeling and ultimately lead to the development of heart failure. The study of cardiac aging is helpful to explore the mechanism of senescence and is of great significance for preventing cardiac aging. Cardiac aging is accompanied by changes in various metabolic functions. In this process, due to the change of metabolic substrates and enzyme activities, oxidative stress response increases, and reactive oxygen species (ROS) increases, accompanied by mitochondrial dysfunction and gene expression changes, so related protein metabolism also changes. Hormone metabolism and autophagy are also involved in the process of cardiac aging. Based on these findings, changes in diet, caloric restriction, improvement of mitochondrial function and promotion of autophagy have been proven to have positive effects in delaying cardiac aging. This article reviews the metabolic changes involved in the process of cardiac aging from different aspects, and briefly reviews the measures to improve cardiac aging.
心脏衰老 是一个伴随着心肌细胞肥大和功能障碍的自然过程。这些变化会导致不良的器官重塑，并最终导致心力衰竭的发生。对心脏衰老的研究有助于探索衰老机制，对预防心脏衰老具有重要意义。心脏衰老伴随着各种代谢功能的变化。在此过程中，由于代谢底物和酶活性的改变，氧化应激反应增强，活性氧（ROS）增加，同时伴有线粒体功能障碍和基因表达变化，因此相关的蛋白质代谢也会发生改变。激素代谢和自噬也参与心脏衰老过程。基于这些发现，饮食改变、热量限制、改善线粒体功能和促进自噬已被证明在延缓心脏衰老方面具有积极作用。本文从不同方面综述了心脏衰老过程中涉及的代谢变化，并简要回顾了改善心脏衰老的措施。
