Markousis-Mavrogenis George, Sfikakis Petros P, Kwong Anne Hui Sze, Pepe Alessia, Matucci-Cerinic Marco, Kitas George D, Mavrogeni Sophie I
University Research Institute of Maternal and Child Health and Precision Medicine and UNESCO Chair in Adolescent Health Care, Medical School, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 11527 Athens, Greece.
Joint Rheumatology, Laikon Hospital, National and Kapodistrian University of Athens, 15772 Athens, Greece.
Rev Cardiovasc Med. 2023 Oct 12;24(10):290. doi: 10.31083/j.rcm2410290. eCollection 2023 Oct.
Patients with systemic autoimmunity due to autoimmune rheumatic diseases (ARDs) or sarcoidosis frequently present with systemic manifestations including cardiac involvement. Cardiac rhythm disturbances and specifically ventricular arrhythmias (VAs) may affect the prognosis of these patients. Cardiovascular magnetic resonance imaging (CMR) is a non-invasive imaging modality that can provide valuable diagnostic and prognostic information in patients with ARDs or systemic autoimmunity in general. In this narrative review, we briefly present the underlying pathophysiologic mechanisms contributing to arrhythmogenicity in patients with systemic autoimmunity. Furthermore, we discuss recent advances underlying the role and value of CMR for use in the detection and risk stratification of arrhythmogenic substrates in patients with systemic autoimmunity and VAs.
患有自身免疫性风湿性疾病（ARDs）或结节病所致全身性自身免疫的患者常出现包括心脏受累在内的全身表现。心律紊乱，特别是室性心律失常（VAs）可能影响这些患者的预后。心血管磁共振成像（CMR）是一种非侵入性成像方式，一般可为患有ARDs或全身性自身免疫的患者提供有价值的诊断和预后信息。在这篇叙述性综述中，我们简要介绍了导致全身性自身免疫患者发生心律失常的潜在病理生理机制。此外，我们还讨论了CMR在全身性自身免疫和室性心律失常患者致心律失常基质的检测及风险分层中的作用和价值方面的最新进展。
