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胸痛患者的当代生物标志物策略

Contemporary Biomarker Strategies for Patients with Chest Pain.

作者信息

Boone Stephen, Peacock W Frank

机构信息

Department of Emergency Medicine, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

出版信息

Rev Cardiovasc Med. 2022 Apr 27;23(5):157. doi: 10.31083/j.rcm2305157. eCollection 2022 May.

DOI:10.31083/j.rcm2305157
PMID:39077617
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11273972/
Abstract

This review focuses on the strengths and limitations of conventional and high-sensitivity troponin in the evaluation of patients with suspected acute coronary syndromes. High-sensitivity troponin (hsTn) assays represent a significant innovation over prior generation troponin assays. Owing to superior analytical precision, hsTn permits more rapid "rule-in" and "rule-out" of myocardial infarction. Furthermore, hsTn assays, in properly implemented clinical pathways, permit a reduction in the portion of patients requiring extended observation and testing.

摘要

本综述重点关注传统肌钙蛋白和高敏肌钙蛋白在疑似急性冠脉综合征患者评估中的优势与局限性。高敏肌钙蛋白(hsTn)检测相较于前代肌钙蛋白检测是一项重大创新。由于具有卓越的分析精密度,hsTn能更快速地“诊断”和“排除”心肌梗死。此外,在合理实施的临床路径中,hsTn检测可减少需要延长观察和检测的患者比例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1433/11273972/0997cb448c5c/2153-8174-23-5-157-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1433/11273972/1e07ce871bd6/2153-8174-23-5-157-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1433/11273972/0997cb448c5c/2153-8174-23-5-157-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1433/11273972/1e07ce871bd6/2153-8174-23-5-157-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1433/11273972/0997cb448c5c/2153-8174-23-5-157-g2.jpg

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本文引用的文献

1
2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR 胸痛评估与诊断指南:美国心脏病学会/美国心脏协会联合临床实践指南委员会的报告。
Circulation. 2021 Nov 30;144(22):e368-e454. doi: 10.1161/CIR.0000000000001029. Epub 2021 Oct 28.
2
Cardiac Troponin and the True False Positive.心肌肌钙蛋白与真、假阳性
JACC Case Rep. 2020 Mar 18;2(3):461-463. doi: 10.1016/j.jaccas.2020.01.012. eCollection 2020 Mar.
3
Discordance of High-Sensitivity Troponin Assays in Patients With Suspected Acute Coronary Syndromes.
高敏肌钙蛋白检测在疑似急性冠脉综合征患者中的不准确性。
J Am Coll Cardiol. 2021 Mar 30;77(12):1487-1499. doi: 10.1016/j.jacc.2021.01.046.
4
Independent and combined effects of biotin and hemolysis on high-sensitivity cardiac troponin assays.生物素和溶血对高敏心肌肌钙蛋白检测的独立和联合影响。
Clin Chem Lab Med. 2021 Mar 25;59(8):1431-1443. doi: 10.1515/cclm-2021-0124. Print 2021 Jul 27.
5
Diagnostic Performance of High-Sensitivity Cardiac Troponin T Strategies and Clinical Variables in a Multisite US Cohort.美国多中心队列中高敏心肌肌钙蛋白T检测策略与临床变量的诊断效能
Circulation. 2021 Apr 27;143(17):1659-1672. doi: 10.1161/CIRCULATIONAHA.120.049298. Epub 2021 Jan 21.
6
The Diagnostic Accuracy of the Emergency Department Assessment of Chest Pain (EDACS) Score: A Systematic Review and Meta-analysis.急诊科胸痛评估评分(EDACS 评分)的诊断准确性:系统评价和荟萃分析。
Ann Emerg Med. 2021 Apr;77(4):433-441. doi: 10.1016/j.annemergmed.2020.10.020. Epub 2021 Jan 16.
7
Clinically relevant adverse cardiovascular events in intermediate heart score patients admitted to the hospital following a negative emergency department evaluation.经急诊科评估为阴性后住院的中危心脏评分患者中的临床相关不良心血管事件。
Am J Emerg Med. 2021 Aug;46:469-475. doi: 10.1016/j.ajem.2020.10.065. Epub 2020 Nov 3.
8
The disutility of stress testing in low-risk HEART Pathway patients.低危 HEART 路径患者进行压力测试的不便利性。
Am J Emerg Med. 2021 Jul;45:227-232. doi: 10.1016/j.ajem.2020.08.032. Epub 2020 Aug 15.
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Clin Chem. 2020 Sep 1;66(9):1146-1149. doi: 10.1093/clinchem/hvaa160.
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Rev Cardiovasc Med. 2020 Jun 30;21(2):191-203. doi: 10.31083/j.rcm.2020.02.17.