计算机化胎心监护与胎儿心脏对母体摄入咖啡的反应：一项前瞻性研究。

Computerized cardiotocography and fetal heart response to maternal coffee intake: a prospective study.

作者信息

La Verde Marco, Vastarella Maria G, Savoia Fabiana, Capristo Carlo, Marrapodi Maria M, Tesorone Marina, Lettieri Davide, De Franciscis Pasquale, Colacurci Nicola, Morlando Maddalena

机构信息

Unit of Obstetrics and Gynecology, Department of Woman, Child and General and Specialized Surgery, Luigi Vanvitelli University of Campania, Naples, Italy.

Department of Pediatrics, Luigi Vanvitelli University of Campania, Naples, Italy.

出版信息

Minerva Obstet Gynecol. 2025 Feb;77(1):4-11. doi: 10.23736/S2724-606X.24.05406-X. Epub 2024 Jul 30.

DOI:10.23736/S2724-606X.24.05406-X

PMID:39078201

Abstract

BACKGROUND

The aim of this study was to determine the effect of caffeine on fetal heart rate (FHR) as determined by computerized cardiotocography (cCTG) parameters.

METHODS

Term pregnancies that performed a fetal antepartum cCTG were included. Two physicians recorded coffee habits before the cCTG, and pregnant women were divided into two groups: the coffee group and the control group. Furthermore, cCTG' parameters were compared between the two groups.

RESULTS

One hundred thirty-four pregnant women were enrolled. Based on maternal coffee habits, 82 pregnant women were allocated to the coffee group, while 52 were in the control group. The two groups shared similar demographic and obstetric characteristics. The mean daily coffee intake was 1.4±0.6 cups. Coffee group fetuses evidenced a lower FHR baseline, 135±9.9 bpm, versus the control group, 138±8.0 bpm, (P value = 0.03). Other cCTG parameters did not show statistical differences. Multivariate analysis demonstrated no confounding factors. A subanalysis that evaluated the daily amount of coffee consumed or the half-life of caffeine found no difference in cCTG measures.

CONCLUSIONS

Maternal caffeine consumption did not influence fetal cardiac reactivity after absorption.

摘要

背景

本研究的目的是通过计算机化心动图（cCTG）参数来确定咖啡因对胎儿心率（FHR）的影响。

方法

纳入进行胎儿产前cCTG检查的足月妊娠孕妇。两名医生在进行cCTG检查前记录咖啡饮用习惯，孕妇被分为两组：咖啡组和对照组。此外，比较两组的cCTG参数。

结果

共纳入134名孕妇。根据孕妇的咖啡饮用习惯，82名孕妇被分配到咖啡组，52名孕妇被分配到对照组。两组在人口统计学和产科特征方面相似。平均每日咖啡摄入量为1.4±0.6杯。咖啡组胎儿的FHR基线较低，为135±9.9次/分钟，而对照组为138±8.0次/分钟，（P值=0.03）。其他cCTG参数无统计学差异。多变量分析显示无混杂因素。一项评估每日咖啡摄入量或咖啡因半衰期的亚分析发现，cCTG测量结果无差异。