DeWood M A, Amsterdam E A
Cardiology. 1985;72(5-6):255-79. doi: 10.1159/000173884.
Since coronary thrombosis is the final common pathway by which acute transmural myocardial infarction occurs, intracoronary thrombolytic reperfusion has taken on new significance. The goals of early restoration of coronary blood flow are to reduce mortality as well as to demonstrate improvement of markers of success or failure associated with thrombolytic therapy relative to nonreperfused patients. This paper examines clinical studies from multiple centers and the results derived from these studies. Mortality, left ventricular function, electrocardiographic indices of necrosis, laboratory studies, enzymatic indices of myocardial infarction size, thallium perfusion, and scintigraphic studies from controlled randomized and nonrandomized studies are presented. Overall, it appears that thrombolytic reperfusion is beneficial if applied early, although the markers of success or failure do not necessarily correlate with short-term mortality.
由于冠状动脉血栓形成是急性透壁性心肌梗死发生的最终共同途径，冠状动脉内溶栓再灌注具有了新的意义。早期恢复冠状动脉血流的目标是降低死亡率，并证明与未再灌注患者相比，溶栓治疗成功或失败的标志物有所改善。本文研究了多个中心的临床研究以及这些研究得出的结果。呈现了来自对照随机和非随机研究的死亡率、左心室功能、坏死的心电图指标、实验室研究、心肌梗死面积的酶学指标、铊灌注和闪烁扫描研究。总体而言，早期应用溶栓再灌注似乎是有益的，尽管成功或失败的标志物不一定与短期死亡率相关。
