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[自体碎软骨植入治疗肱骨小头局灶性软骨损伤]

[Autologous minced cartilage implantation for focal cartilage lesions of the humeral capitellum].

作者信息

Ott Nadine, Hackl Michael, Müller Lars Peter, Leschinger Tim

机构信息

Klinik und Poliklinik für Orthopädie, Unfallchirurgie und Plastisch-Ästhetische Chirurgie, Schwerpunkt für Unfall‑, Hand- und Ellenbogenchirurgie, Medizinische Fakultät, Universitätsklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

出版信息

Oper Orthop Traumatol. 2024 Aug;36(3-4):188-197. doi: 10.1007/s00064-024-00849-7. Epub 2024 Jul 29.

Abstract

OBJECTIVE

The goal of minced cartilage implantation (MCI) is to restore an intact cartilage surface in focal osteochondral lesions of the humeral capitellum.

INDICATIONS

The indications for MCI are limited osteochondral lesions at the humeral capitellum, also at the head of the radius, with intact cartilage border as well as in situ or a completely detached fragment, and free joint bodies (grade II-grade V according to Hefti).

CONTRAINDICATIONS

Contraindications for MCI are already concomitant or associated cartilage damage as well as bilateral osteochondral lesions and insufficient available cartilage material.

SURGICAL TECHNIQUE

After diagnostic arthroscopy to detect possible concomitant pathologies and to exclude already corresponding cartilage lesions, the arthroscope is flipped posterolaterally over the high posterolateral portal and a second portal is created under visualization via the soft spot. Initially, debridement of the focal cartilage defect, assessment of the marginal zone, and/or salvage of free joint bodies. Using a smooth shaver and the filter provided, the partially or even completely detached cartilage fragment is unidirectionally fragmented under continuous suction. The remaining defect with a stable marginal zone is cleanly curetted, and the joint is completely dried. The fragmented cartilage collected in the filter is bonded to a membrane using autologous conditioned plasma (ACP) and then arthroscopically applied to the defect via a cannula, sealed using thrombin and fibrin.

POSTOPERATIVE MANAGEMENT

Postoperative immobilization in a cast for at least 24 h is required. Afterwards, free exercise of the joint is possible, but no loading should be maintained for 6 weeks. Return to sport after 3 months.

RESULTS

Good to very good clinical and MRI morphologic results are already evident in the short-term course. Prospective and retrospective multicenter studies are needed to evaluate future long-term results.

摘要

目的

碎软骨植入术(MCI)的目标是恢复肱骨小头局灶性骨软骨损伤处完整的软骨表面。

适应症

MCI的适应症为肱骨小头以及桡骨头处的局限性骨软骨损伤,软骨边缘完整,存在原位或完全分离的碎片,以及游离关节体(根据赫夫蒂分级为II级至V级)。

禁忌症

MCI的禁忌症包括已有的伴随或相关软骨损伤、双侧骨软骨损伤以及可用软骨材料不足。

手术技术

在进行诊断性关节镜检查以检测可能的伴随病变并排除相应的软骨损伤后,将关节镜通过后外侧高位通道翻转至后外侧,通过软点在可视状态下创建第二个通道。首先,对局灶性软骨缺损进行清创,评估边缘区域,和/或挽救游离关节体。使用光滑的刨削器和提供的滤网,在持续吸引下将部分或甚至完全分离的软骨碎片单向破碎。对边缘区域稳定的剩余缺损进行彻底刮除,并将关节完全擦干。收集在滤网中的破碎软骨使用自体条件血浆(ACP)粘结到膜上,然后通过套管经关节镜应用于缺损处,用凝血酶和纤维蛋白密封。

术后管理

术后需要用石膏固定至少24小时。之后,可以进行关节的自由活动,但6周内不应负重。3个月后恢复运动。

结果

在短期病程中已可见良好至非常好的临床和MRI形态学结果。需要进行前瞻性和回顾性多中心研究以评估未来的长期结果。

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