Schneider Stefan, Ossendorff Robert, Holz Johannes, Salzmann Gian M
Orthocentrum Hamburg, Hamburg.
Department for Orthopaedics and Trauma, University Hospital Bonn, Bonn.
Arthrosc Tech. 2020 Dec 19;10(1):e97-e101. doi: 10.1016/j.eats.2020.09.015. eCollection 2021 Jan.
Articular cartilage lesions are identified with increasing frequency. Several cartilage repair techniques are available to treat symptomatic cartilage defects. The ultimate goal of any cartilage repair procedure is the prevention of premature osteoarthritis. Autologous chondrocyte implantation provides the best tissue quality. However, 2 operations and a resource-intense culturing process with high regulatory demands are disadvantages of this cartilage repair procedure. Furthermore, cellular dedifferentiation and senescence display further cell culture-associated drawbacks that hamper the procedure. Minced cartilage implantation is a relatively simple and cost-effective one-step procedure with promising biologic potential and satisfying clinical results. We present an arthroscopic surgical technique where the surgeon can apply autologous chondrocytes in a one-step procedure to treat articular cartilage defects at the knee joint.
关节软骨损伤的发现频率越来越高。有几种软骨修复技术可用于治疗有症状的软骨缺损。任何软骨修复手术的最终目标都是预防过早发生骨关节炎。自体软骨细胞植入可提供最佳的组织质量。然而,该软骨修复手术存在两个缺点,即需要进行两次手术以及培养过程资源密集且监管要求高。此外,细胞去分化和衰老显示出与细胞培养相关的其他缺点,这阻碍了该手术的进行。碎软骨植入是一种相对简单且经济高效的一步手术,具有良好的生物学潜力和令人满意的临床效果。我们介绍一种关节镜手术技术,外科医生可以通过该技术在一步手术中应用自体软骨细胞来治疗膝关节的关节软骨缺损。