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Neurotransmitter Switching: A Novel Mechanism for Fear Generalization.

作者信息

Zheng Jiayuan, Tian Zhanzhuang

机构信息

Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Institute of Acupuncture Research, Academy of Integrative Medicine, Shanghai Key Laboratory for Acupuncture Mechanism and Acupoint Function, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

出版信息

Neurosci Bull. 2024 Dec;40(12):2015-2018. doi: 10.1007/s12264-024-01264-5. Epub 2024 Jul 29.

DOI:10.1007/s12264-024-01264-5
PMID:39078593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11625032/
Abstract
摘要

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Generalized fear after acute stress is caused by change in neuronal cotransmitter identity.急性应激后广泛性恐惧是由神经元共递质特性改变引起的。
Science. 2024 Mar 15;383(6688):1252-1259. doi: 10.1126/science.adj5996. Epub 2024 Mar 14.
2
Fluoxetine combined with swimming exercise synergistically reduces lipopolysaccharide-induced depressive-like behavior by normalizing the HPA axis and brain inflammation in mice.氟西汀联合游泳运动通过调节 HPA 轴和脑内炎症发挥协同作用，减轻脂多糖诱导的小鼠抑郁样行为。
Pharmacol Biochem Behav. 2023 Nov;232:173640. doi: 10.1016/j.pbb.2023.173640. Epub 2023 Sep 21.
3
Hypothalamic deep brain stimulation as a strategy to manage anxiety disorders.下丘脑深部脑刺激作为一种管理焦虑障碍的策略。
Proc Natl Acad Sci U S A. 2022 Apr 19;119(16):e2113518119. doi: 10.1073/pnas.2113518119. Epub 2022 Apr 11.
4
Decoding Neurotransmitter Switching: The Road Forward.解码神经递质转换：前进之路。
J Neurosci. 2020 May 20;40(21):4078-4089. doi: 10.1523/JNEUROSCI.0005-20.2020.
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Anterior Cingulate Cortex to Ventral Hippocampus Circuit Mediates Contextual Fear Generalization.前扣带皮层到海马腹侧回路介导情境恐惧泛化。
J Neurosci. 2019 Jul 17;39(29):5728-5739. doi: 10.1523/JNEUROSCI.2739-18.2019. Epub 2019 May 16.
6
Perspectives on fear generalization and its implications for emotional disorders.恐惧泛化及其对情绪障碍的影响的观点。
J Neurosci Res. 2017 Mar;95(3):821-835. doi: 10.1002/jnr.23837. Epub 2016 Jul 22.
7
Neurotransmitter Switching? No Surprise.神经递质转换？不足为奇。
Neuron. 2015 Jun 3;86(5):1131-44. doi: 10.1016/j.neuron.2015.05.028.
8
Neuronal circuits for fear and anxiety.恐惧和焦虑的神经回路。
Nat Rev Neurosci. 2015 Jun;16(6):317-31. doi: 10.1038/nrn3945.
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Neurotransmitter switching in the adult brain regulates behavior.成年人大脑中的神经递质转换调节行为。
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Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic-pituitary-adrenal axis.快速糖皮质激素反馈抑制下丘脑-垂体-肾上腺轴的机制。
Stress. 2011 Jul;14(4):398-406. doi: 10.3109/10253890.2011.586446.