Ucar Didar, Bircan Basak Ecem, Rustamli Nigar, Batu Oto Bilge, Hamuryudan Vedat, Hatemi Gulen, Esatoglu Sinem Nihal
Department of Ophthalmology, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Türkiye.
Behçet's Disease Research Center, Istanbul University-Cerrahpasa, Istanbul, Türkiye.
Ocul Immunol Inflamm. 2025 Feb;33(2):243-249. doi: 10.1080/09273948.2024.2383315. Epub 2024 Jul 30.
The prognostic importance of vitreous cells (VC) in patients with Behçet syndrome (BS) is unknown. We aimed to determine the frequency of developing posterior uveitis (PU) and any additional risk factors associated with the development of PU in BS patients with VC at diagnosis.
The charts of 572 consecutive BS patients who were registered between 2010 and 2012 were reviewed. Among the patients with a follow-up of ≥2 years, we included 110 patients with VC in one or both eyes and 147 patients without any eye findings in both eyes at baseline and compared them for the development of PU.
Among the 110 included patients with VC, 61 had VC in both eyes, 34 had VC in only one eye, and 15 had VC in one eye and PU in the other eye. There was anterior uveitis (AU) in addition to VC in the same eye in 13 patients at baseline. PU developed in 24 (22%) of these patients during a mean follow-up of 1.9 ± 1.1 years. This was significantly more frequent than the 147 patients without any eye findings at baseline, among whom there were only 2 patients who developed PU ( < 0.001). Multivariate logistic regression analysis showed that having AU in addition to VC in the same eye (OR, 5.03, 95% CI; 1.37-18.47) was an independent risk factor for the development of PU in patients with VC.
Careful follow-up is required for patients with VC at diagnosis, since 22% developed PU within 2 years.
白塞病（BS）患者玻璃体细胞（VC）的预后重要性尚不清楚。我们旨在确定诊断时有VC的BS患者发生后葡萄膜炎（PU）的频率以及与PU发生相关的任何其他危险因素。
回顾了2010年至2012年间登记的572例连续BS患者的病历。在随访时间≥2年的患者中，我们纳入了110例一只或两只眼睛有VC的患者以及147例基线时双眼无任何眼部病变的患者，并比较他们PU的发生情况。
在纳入的110例有VC的患者中，61例双眼有VC，34例仅一只眼睛有VC，15例一只眼睛有VC而另一只眼睛有PU。13例患者基线时同一眼中除VC外还有前葡萄膜炎（AU）。在平均1.9±1.1年的随访期间，这些患者中有24例（22%）发生了PU。这明显高于147例基线时无任何眼部病变的患者，其中只有2例发生了PU（<0.001）。多因素逻辑回归分析显示，同一眼中除VC外还有AU（比值比，5.03，95%可信区间；1.37-18.47）是有VC患者发生PU的独立危险因素。
诊断时有VC的患者需要仔细随访，因为有22%的患者在2年内发生了PU。
