左西孟旦在延长机械通气撤机和心功能障碍患者中的治疗效果。
The therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction.
机构信息
Postgraduate School, Jinzhou Medical University, Jinzhou, Liaoning, China.
Department of Critical Care Medicine, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, China.
出版信息
J Int Med Res. 2024 Jul;52(7):3000605241263166. doi: 10.1177/03000605241263166.
OBJECTIVE
To explore the therapeutic effect of levosimendan in patients with prolonged ventilator weaning and cardiac dysfunction.
METHOD
Patients with prolonged ventilator weaning and cardiac dysfunction were randomly allocated to receive conventional treatment (control group) or intravenous infusion of levosimendan for 24 h based on conventional treatment (levosimendan group). Weaning success rates were then compared between the two groups. The study was retrospectively registered with Research Registry (ID No. researchregistry10304).
RESULTS
A total of 40 patients were included (20 per group). Within 3 days after initiation of treatment, significantly more cases were successfully weaned in the levosimendan group versus control group (eight versus four cases, respectively). Among the eight patients who underwent pulse indicator continuous cardiac output monitoring in the levosimendan group, the global ejection fraction increased 24 h after treatment, and the cardiac function index and cardiac index increased 72 h after treatment.
CONCLUSION
For patients requiring prolonged mechanical ventilation who have concomitant cardiac dysfunction, levosimendan may be considered to increase the probability of weaning success.
目的
探讨左西孟旦治疗机械通气时间延长合并心功能障碍患者的疗效。
方法
将机械通气时间延长合并心功能障碍的患者随机分为常规治疗组（对照组）或在常规治疗基础上静脉输注左西孟旦 24 h 组（左西孟旦组）。比较两组患者的撤机成功率。本研究在 Research Registry （注册号：researchregistry10304）上进行了回顾性注册。
结果
共纳入 40 例患者（每组 20 例）。治疗开始后 3 天内，左西孟旦组的撤机成功率明显高于对照组（8 例比 4 例）。在左西孟旦组中，8 例接受脉搏指示剂连续心输出量监测的患者在治疗后 24 h 时整体射血分数增加，心功能指数和心指数在治疗后 72 h 时增加。
结论
对于需要长时间机械通气且合并心功能障碍的患者，左西孟旦可考虑增加撤机成功率。
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