Division of Infectious Diseases, Department of Pediatrics, Levine Children's Hospital at Atrium Health and Wake Forest University School of Medicine, Charlotte, North Carolina, USA.
Curr Opin Infect Dis. 2024 Oct 1;37(5):413-418. doi: 10.1097/QCO.0000000000001043. Epub 2024 Jul 24.
The American Academy of Pediatrics recently published guidance for the evaluation and management of febrile infants. However, guidance on testing and empiric treatment for neonatal herpes simplex virus (HSV) remains less standardized and subject to clinical practice variation.
Recent reports reveal that high numbers of infants presenting for sepsis evaluations need to be treated empirically with acyclovir to capture one case of neonatal HSV. Clinical and laboratory risk factors for neonatal HSV identified in the literature can be used for a targeted approach to testing and treating infants for HSV to optimize resource utilization.
The literature supports a targeted approach to evaluation and empiric acyclovir treatment for neonatal HSV, but additional studies are needed to validate this approach given the rarity of disease.
美国儿科学会最近发布了发热婴儿评估和管理的指南。然而，对于新生儿单纯疱疹病毒（HSV）的检测和经验性治疗的指南仍然不够标准化，存在临床实践差异。
最近的报告显示，有大量因疑似败血症而接受评估的婴儿需要接受阿昔洛韦的经验性治疗，以捕捉一例新生儿 HSV 感染。文献中确定的新生儿 HSV 的临床和实验室危险因素可用于针对特定人群进行 HSV 的检测和治疗，以优化资源利用。
文献支持针对新生儿 HSV 进行评估和经验性阿昔洛韦治疗的针对性方法，但鉴于疾病的罕见性，还需要进一步的研究来验证这种方法。
