Departments of Dermatology and Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Departments of Dermatology and Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Curr Opin Cell Biol. 2024 Oct;90:102403. doi: 10.1016/j.ceb.2024.102403. Epub 2024 Jul 29.
Cell junctions integrate extracellular signals with intracellular responses to polarize tissues, pattern organs, and maintain tissue architecture by promoting cell-cell adhesion and communication. In this review, we explore the mechanisms whereby the adhesive junctions, adherens junctions and desmosomes, co-assemble and then segregate into unique plasma membrane domains. In addition, we highlight emerging evidence that these junctions are spatially and functionally integrated with the endoplasmic reticulum to mediate stress sensing and calcium homeostasis. We conclude with a discussion of the role of the endoplasmic reticulum in the mechanical stress response and how disruption of these connections may cause disease.
细胞连接整合细胞外信号和细胞内反应，通过促进细胞间黏附和通讯来极化组织、塑造器官和维持组织架构。在这篇综述中，我们探讨了黏附连接、黏着斑和桥粒协同组装，然后分离成独特的质膜域的机制。此外，我们还强调了新出现的证据表明这些连接与内质网在空间和功能上是整合的，以介导应激感应和钙稳态。最后，我们讨论了内质网在机械应激反应中的作用，以及这些连接的破坏如何导致疾病。
