Department of Nursing, Faculty of Medicine, University of Novi Sad, Novi Sad.
Department of Orthopedic Surgery and Traumatology, Clinical Center of Vojvodina, Novi Sad.
Cir Cir. 2024;92(4):525-531. doi: 10.24875/CIRU.23000578.
The number of participants in sports or some form of recreation globally has led to an increase in the incidence of anterior cruciate ligament (ACL) injuries and the number of surgeries performed. Although it does not belong to risky surgical interventions, this operation is accompanied by complications that slow down post-operative rehabilitation. The objective is to analyze the effects of intra-articular (IA) injection of tranexamic acid (TXA) on the reduction of post-operative drained blood volume, pain intensity, and incidence of hemarthrosis after ACL reconstruction.
This prospective research included 124 patients undergoing ACL reconstruction surgery, randomly divided into two groups. The TXA group received IA TXA, whereas an equal amount of placebo was administered using the same route in the control group.
The research has shown that IA injection of TXA effectively reduces post-operative blood loss (TXA group 71.29 ± 40.76 vs. control group 154.35 ± 81.45), reducing the intensity of post-operative pain (p < 0.001) and the incidence of hemarthrosis.
The application of TXA significantly reduced post-operative bleeding and pain intensity, which accelerated the post-operative period.
全球参与运动或某种形式娱乐活动的人数增加，导致前交叉韧带（ACL）损伤的发病率和手术数量增加。尽管它不属于高风险的手术干预，但这种手术伴随着会减缓术后康复的并发症。本研究旨在分析关节内（IA）注射氨甲环酸（TXA）对减少 ACL 重建术后引流血量、疼痛强度和关节积血发生率的影响。
这项前瞻性研究纳入了 124 例行 ACL 重建手术的患者，随机分为两组。TXA 组接受 IA TXA，对照组则采用相同途径给予等量安慰剂。
研究表明，IA 注射 TXA 可有效减少术后失血（TXA 组 71.29 ± 40.76 比对照组 154.35 ± 81.45），减轻术后疼痛强度（p < 0.001）和关节积血发生率。
TXA 的应用显著减少了术后出血和疼痛强度，加速了术后恢复。
