Department of Vascular Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Department of Oncological Radiotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Biomed Pharmacother. 2024 Sep;178:117183. doi: 10.1016/j.biopha.2024.117183. Epub 2024 Jul 30.
Atherosclerosis, characterized by the accumulation of plaque within the arterial walls, is an intricate cardiovascular disease that often results in severe health issues. Recent studies have emphasized the importance of ferroptosis, a controlled type of cell death dependent on iron, as a critical factor in this disease state. Ferroptosis, distinguished by its reliance on iron and the accumulation of lipid hydroperoxides, offers a unique insight into the pathology of atherosclerotic lesions. This summary encapsulates the current knowledge of the intricate role ferroptosis plays in the onset and progression of atherosclerosis. It explores the molecular processes through which lipid peroxidation and iron metabolism contribute to the development of atheromatous plaques and evaluates the possibility of utilizing ferroptosis as a novel treatment approach for atherosclerosis. By illuminating the intricate relationship between ferroptosis-related processes and atherosclerosis, this review paves the way for future clinical applications and personalized medicine approaches aimed at alleviating the effects of atherosclerosis.
动脉粥样硬化，其特征是动脉壁内斑块的积累，是一种复杂的心血管疾病，常常导致严重的健康问题。最近的研究强调了铁依赖性细胞死亡的一种受控形式——铁死亡，作为这种疾病状态的一个关键因素的重要性。铁死亡的特征是依赖于铁和脂质过氧化物的积累，为动脉粥样硬化病变的病理学提供了独特的见解。本综述总结了铁死亡在动脉粥样硬化发生和进展中所起的复杂作用的现有知识。它探讨了脂质过氧化和铁代谢如何通过分子过程促进动脉粥样硬化斑块的形成，并评估了将铁死亡作为动脉粥样硬化的一种新的治疗方法的可能性。通过阐明铁死亡相关过程与动脉粥样硬化之间的复杂关系，本综述为未来旨在缓解动脉粥样硬化影响的临床应用和个体化医学方法铺平了道路。
