Epifanova O I
Tsitologiia. 1979 Dec;21(12):1379-96.
This review concerns the modern trends and experimental approaches to the study of cell cycle (cell population kinetics, cell structure and functions at various steps of the cycle,, etc.) and their input into the current views of cell proliferation controls. The resting state of the cell is considered and metabolic features of proliferating and resting cells are compared. Evidence is presented that resting cells are metabolically active and less resistant to the damaging factors that it has been previously supposed. The importance of this finding for biology and medicine, especially for cancer chemotherapy, is discussed.
本综述涉及细胞周期研究的现代趋势和实验方法(细胞群体动力学、细胞周期各阶段的细胞结构和功能等)及其对当前细胞增殖调控观点的贡献。文中探讨了细胞的静止状态,并比较了增殖细胞和静止细胞的代谢特征。有证据表明,静止细胞具有代谢活性,且对损伤因素的耐受性比之前认为的要低。本文还讨论了这一发现对生物学和医学,尤其是对癌症化疗的重要性。