Matthias M
Acta Histochem Suppl. 1983;27:95-104.
Cell proliferation is an essential premise for the cell-destroying action of antineoplastic chemotherapy. A survey is given on the growth behaviour of malignant neoplasms, on the cell cycle-dependent mode of action of antineoplastic chemotherapeutics as well as on the consequences of this cell kinetic knowledge for medical practice. Though research on cell kinetics of normal and tumor cell populations has yielded many useful data for the design of tumor therapy schedules in medical practice it is hitherto scarcely possible to improve selective treatment by means of cell kinetic parameters in the next future. Further investigations in normal (mainly bone marrow) and neoplastic cell populations concerning their sensitivity to cytostatic chemotherapy as well as deeper insights in molecular biological processes during the different phases of the cell cycle and subtle analyses of the growth behaviour of tumor stem cells are inevitable.
细胞增殖是抗肿瘤化疗细胞杀伤作用的重要前提。本文综述了恶性肿瘤的生长行为、抗肿瘤化疗药物的细胞周期依赖性作用方式，以及这种细胞动力学知识在医学实践中的应用。尽管对正常细胞和肿瘤细胞群体的细胞动力学研究已经为医学实践中肿瘤治疗方案的设计提供了许多有用的数据，但在可预见的未来，几乎不可能通过细胞动力学参数来改善选择性治疗。对正常细胞（主要是骨髓细胞）和肿瘤细胞群体对细胞毒性化疗的敏感性进行进一步研究，深入了解细胞周期不同阶段的分子生物学过程，并对肿瘤干细胞的生长行为进行精细分析是必不可少的。
