Interdisciplinary Research Center in Biomedical Materials (IRCBM), COMSATS University, Islamabad, Lahore Campus, Lahore 54000, Pakistan; Department of Chemistry, COMSATS University Islamabad, Lahore Campus, Lahore-54600, Pakistan.
Department of Biochemistry, Gulab Devi Educational Complex, Gulab Devi Hospital, Lahore 05307, Pakistan.
Food Chem. 2024 Dec 1;460(Pt 1):140297. doi: 10.1016/j.foodchem.2024.140297. Epub 2024 Jul 2.
A facile and simple electrochemical composite sensor, CDs-Ag@CuO-GA, prepared from carbon dots stabilized silver nanoparticles and copper oxide, was used as an electrocatalyst and signal amplifier for the non-enzymatic detection of antibiotic traces in food products. The prepared composite demonstrated excellent stability, sensitivity, and cost-effectiveness. The sensor was constructed by modifying a glassy carbon electrode (GCE) with CDs-Ag@CuO-GA, and the electroanalytical response was determined for the precise determination of metronidazole (MTZ) drug traces in milk. The analytical response signified fast electron transfer and accessibility of several electroactive sites, producing an amplified response for the reduction of MTZ. The quantitative analysis by the sensor revealed a good linear range (10-110 μM), a low limit of detection (7.1 × 10 molL), and a high sensitivity (1.5 μA μM cm). Furthermore, the sensor displayed excellent potential for practical applications, verified by the good recovery of the drug from spiked milk samples.
一种简单易用的电化学复合传感器，即 CDs-Ag@CuO-GA，由碳点稳定的银纳米粒子和氧化铜组成，被用作电催化剂和信号放大器，用于非酶法检测食品中抗生素痕量。所制备的复合材料表现出极好的稳定性、灵敏度和性价比。该传感器通过在玻碳电极（GCE）上修饰 CDs-Ag@CuO-GA 构建而成，并对牛奶中甲硝唑（MTZ）药物痕量进行了精确的电化学响应测定。分析响应表明，快速的电子转移和多个电活性位点的可及性，为 MTZ 的还原产生了放大的响应。传感器的定量分析显示出良好的线性范围（10-110 μM）、低检测限（7.1×10-7 molL）和高灵敏度（1.5 μA μM cm）。此外，该传感器在实际应用中表现出优异的潜力，通过从加标牛奶样品中回收药物得到了验证。
