2005-2016 年 NHANES 调查：生活简单 7 项指标与卒中后抑郁症状的相关性：一项横断面研究。
Association between Life's simple 7 and post-stroke depression symptom from 2005-2016 NHANES survey: A cross-sectional study.
机构信息
The National Key Clinic Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
The National Key Clinic Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
出版信息
J Psychiatr Res. 2024 Sep;177:346-351. doi: 10.1016/j.jpsychires.2024.07.005. Epub 2024 Jul 8.
BACKGROUND
Depression symptoms are a common complication of stroke and heart disease and is a predictor of Post-stroke depression (PSD). However, the relationship between overall cardiovascular health indicators and PSD remains unclear.
METHODS
Data were collected from stroke patients in the 2005-2016 National Health and Nutrition Examination Surveys (NHANES) survey. Depression was defined as a Patient Health Questionnaire-9 (PHQ-9) score ≥10. In addition, PSD was defined as the coexistence of stroke and depression. Life's Simple 7 (LS7) provides an assessment of cardiovascular health and consists of 7 items. The LS7 scores range from 0 to 14 and can also be categorized into poor (0-7), average (8-10), and ideal (11-14). Logistic regression models were used to investigate the relationship between LS7 and PSD.
RESULTS
The average age of participants was 64.2 years, with 45.1% and 34.3 % being male and non-Hispanic whites, respectively. After adjusting for age, sex, race, education, and income, the LS7 scores were found to be associated with reduced PSD odds (OR: 0.76, 95% CI: 0.68-0.85, P: <0.001), as well as the number of ideal LS7 metrics (OR: 0.69, 95% CI: 0.56-0.85, P: <0.001). Furthermore, non-poor LS7 was also associated with a lower risk of PSD compared to poor LS7 (OR: 0.48, 95% CI: 0.25-0.91, P: 0.01). This association was stable in stratification analyses.
CONCLUSION
Cardiovascular health status assessed by LS7 was negatively associated with PSD. Future studies are required to verify these findings.
背景
抑郁症状是中风和心脏病的常见并发症，也是中风后抑郁（PSD）的预测因素。然而，整体心血管健康指标与 PSD 之间的关系尚不清楚。
方法
数据来自 2005-2016 年国家健康和营养检查调查（NHANES）调查中的中风患者。抑郁定义为患者健康问卷-9（PHQ-9）得分≥10。此外，PSD 定义为中风和抑郁同时存在。生命的简单 7 项（LS7）提供了心血管健康评估，由 7 项组成。LS7 得分范围为 0 至 14 分，也可以分为差（0-7）、中等（8-10）和理想（11-14）。使用逻辑回归模型研究 LS7 与 PSD 之间的关系。
结果
参与者的平均年龄为 64.2 岁，分别有 45.1%和 34.3%为男性和非西班牙裔白人。在调整年龄、性别、种族、教育程度和收入后，LS7 得分与 PSD 几率降低相关（OR：0.76，95%CI：0.68-0.85，P：<0.001），以及理想 LS7 指标的数量（OR：0.69，95%CI：0.56-0.85，P：<0.001）。此外，非差 LS7 与 PSD 风险降低相关，与差 LS7 相比（OR：0.48，95%CI：0.25-0.91，P：0.01）。分层分析结果稳定。
结论
LS7 评估的心血管健康状况与 PSD 呈负相关。需要进一步的研究来验证这些发现。
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