Yu Wei-Ling, Ma Fu-Zhai, Huang Hua, Xiao Ben-Heng, Li Xin-Ming, Wáng Yì Xiáng J
Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong Faculty of Medicine, Hong Kong.
Department of Radiology, The Third People's Hospital of Shenzhen, Shenzhen, China.
Rofo. 2025 May;197(5):535-545. doi: 10.1055/a-2357-9741. Epub 2024 Jul 30.
This study investigates age and gender differences of normative values of spleen diffusion MRI parameters.We recruited 124 volunteers with MRI conducted at 1.5T. Diffusion imaging had b-values of 0, 2, 4, 7, 10, 15, 20, 30, 46, 60, 72, 100, 150, 200, 400, 600 s/mm. ADC, IVIM-Dslow, IVIM-PF, IVIM-Dfast, and DDVD (diffusion-derived vessel density) were computed. DDVD is the signal difference between the b=0 s/mm image and b=2, 4 s/mm image. Only images without apparent artifacts and with good curving fitting were included in the analysis. Finally, 34 females (age: 20-71 years) and 69 males (22-70 years) were measured with ADC; 20 females (20-71 years) and 48 males (22-67 years) were measured with IVIM; 32 females (20-71 years) and 65 males (22-70 years) were measured with DDVD parameter.An age-related decrease in ADC was noted for females, while such a trend was not noted for males. A very high level of heterogeneity was noted for the data for the males, with the highest ADC value being 1.710 × 10mm /s and the lowest ADC value being 0.705 × 10 mm/s when b=0 and 600 s/mm were used for ADC calculation. A male-female data comparison did not show a statistically significant difference between the ADC median value. However, ADCs > 1.3 × 10 mm/s were only seen among males. A very high level of heterogeneity was also noted for males' Dslow, with the highest value being 1.468 × 10 mm/s and the lowest value being 0.600 × 10 mm/s. Both PF and Dfast demonstrated a trend of age-related increase for older subjects. PF values were higher among males than females. However, no difference was noted for Dfast between males and females. DDVD did not show an age-related trend both for females and males. No difference was noted in DDVD values between males and females.Interpreting normal spleen diffusion MRI parameters should consider age and gender factors. · An age-related decrease in spleen ADC and IVIM-Dslow was seen for healthy females.. · There is a high level of heterogeneity for spleen ADC and IVIM-Dslow data for healthy males.. · IVIM modelled perfusion fraction and Dfast demonstrate an artificial trend of age-related increase for older subjects.. · Vessel density measured on diffusion imaging does not show an age-related trend.. · Yu W, Ma FZ, Huang H et al. Age and gender differences of normative values of spleen diffusion MRI parameters. Rofo 2025; 197: 535-545.
本研究调查脾脏扩散磁共振成像（MRI）参数正常数值的年龄和性别差异。我们招募了124名接受1.5T MRI检查的志愿者。扩散成像的b值为0、2、4、7、10、15、20、30、46、60、72、100、150、200、400、600 s/mm²。计算了表观扩散系数（ADC）、体素内不相干运动-慢扩散系数（IVIM-Dslow）、IVIM-灌注分数（IVIM-PF）、IVIM-快扩散系数（IVIM-Dfast）和扩散衍生血管密度（DDVD）。DDVD是b = 0 s/mm²图像与b = 2、4 s/mm²图像之间的信号差值。分析仅纳入无明显伪影且曲线拟合良好的图像。最后，对34名女性（年龄：20 - 71岁）和69名男性（22 - 70岁）进行了ADC测量；对20名女性（20 - 71岁）和48名男性（22 - 67岁）进行了IVIM测量；对32名女性（20 - 71岁）和65名男性（22 - 70岁）进行了DDVD参数测量。女性的ADC值随年龄下降，而男性未观察到这种趋势。男性数据的异质性非常高，当用于ADC计算的b值为0和600 s/mm²时，最高ADC值为1.710×10⁻³mm²/s，最低ADC值为0.705×10⁻³mm²/s。男性和女性数据比较显示，ADC中位数之间无统计学显著差异。然而，ADC值> 1.3×10⁻³mm²/s仅见于男性。男性的Dslow异质性也非常高，最高值为1.468×10⁻³mm²/s，最低值为0.600×10⁻³mm²/s。PF和Dfast在老年受试者中均呈现随年龄增加的趋势。男性的PF值高于女性。然而，男性和女性的Dfast无差异。DDVD在女性和男性中均未显示出随年龄变化的趋势。男性和女性的DDVD值无差异。解读正常脾脏扩散MRI参数时应考虑年龄和性别因素。· 健康女性的脾脏ADC和IVIM-Dslow随年龄下降。· 健康男性的脾脏ADC和IVIM-Dslow数据存在高度异质性。· IVIM模型的灌注分数和Dfast在老年受试者中呈现随年龄增加的人为趋势。· 扩散成像测量的血管密度未显示随年龄变化的趋势。· 于W，马FZ，黄H等。脾脏扩散MRI参数正常数值的年龄和性别差异。《德国放射学杂志》2025年；197：535 - 545。
