Department of Pharmacy, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan.
International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan.
Planta Med. 2024 Oct;90(12):959-970. doi: 10.1055/a-2376-6380. Epub 2024 Jul 30.
The present study endeavored to design and develop a self-nanoemulsifying drug delivery system to improve the solubility and dermatological absorption of curcumin and naringin. Curcumin and naringin-loaded self-nanoemulsifying drug delivery system formulations were developed using aqueous phase titration. Phase diagrams were used to pinpoint the self-nanoemulsifying drug delivery system zones. Tween 80 and Labrasol (surfactants), Transcutol (cosurfactant), and cinnamon oil were chosen from a large pool of surfactants, cosurfactants, and oils based on their solubility and greatest nano-emulsion region. Fourier transform infrared spectroscopy, zeta sizer, and atomic force microscopy were used to characterize the optimized formulations and test for dilution and thermodynamic stability. The optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated the following characteristics: polydispersity index (0.412 ± 0.03), % transmittance (97%), particle size (212.5 ± 05 nm), zeta potential (- 25.7 ± 1.80 mV) and having a smooth and spherical droplet shape, as shown by atomic force microscopy. The ability of their combined formulation to cure wounds was tested in comparison to pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Upon topical administration, the optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated significant wound healing activity in comparison with a pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Based upon this result, we assume that skin penetration was increased by using the optimized curcumin-naringin-self-nanoemulsifying drug delivery system with enhanced solubility.
本研究旨在设计和开发一种自微乳给药系统，以提高姜黄素和柚皮苷的溶解度和皮肤吸收。采用水相滴定法制备姜黄素和柚皮苷自微乳给药系统制剂。相图用于确定自微乳给药系统区域。根据其溶解度和最大纳米乳液区域，从大量表面活性剂、助表面活性剂和油中选择吐温 80 和 Labrasol（表面活性剂）、Transcutol（助表面活性剂）和肉桂油。傅里叶变换红外光谱、Zeta 粒径仪和原子力显微镜用于表征优化的配方，并测试稀释和热力学稳定性。优化的姜黄素-柚皮苷自微乳给药系统具有以下特征：多分散指数（0.412±0.03）、透光率（97%）、粒径（212.5±05nm）、Zeta 电位（-25.7±1.80mV）和具有光滑的球形液滴形状，原子力显微镜观察结果表明。与纯姜黄素混悬剂、空自微乳给药系统和标准夫西地酸相比，测试其联合配方的伤口愈合能力。局部给药后，与纯姜黄素混悬剂、空自微乳给药系统和标准夫西地酸相比，优化的姜黄素-柚皮苷自微乳给药系统表现出显著的伤口愈合活性。基于这一结果，我们假设通过使用优化的姜黄素-柚皮苷自微乳给药系统提高溶解度，增加了皮肤渗透。
