School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, PR China; Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University, Beijing 100048, PR China.
School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, PR China; Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, Beijing Technology and Business University, Beijing 100048, PR China.
Int J Biol Macromol. 2024 Oct;277(Pt 1):133905. doi: 10.1016/j.ijbiomac.2024.133905. Epub 2024 Jul 30.
Antimicrobial wound dressings can aid wound healing by preventing bacterial infection. This is particularly true of electrospun ones, which have a porous structure and can be easily loaded with antimicrobial drugs. Here, Poly lactic acid (PLA), Silk Fibroin (SF) and antimicrobial agents of Silver nanoparticles (Ag NPs) and Silver oxide (AgO) to prepare the PLA/SF composites antimicrobial nanofiber membrane by electrospinning. The PLA with 30 % SF nanofiber membrane show the water vapor permeability (WVP) and the liquid absorption of 36 g·mm/(m·d·kPa) and 1721 %. With the increasing of SF contents, the degradation rate and surface hydrophilicity of the nanofiber membrane increase significantly. The nanofiber membrane exhibited excellent antimicrobial activity against Pseudomonas aeruginosa (P. aeruginosa) with the inhibition circle reach at 18.2 mm. The resultant nanofiber membrane showed high cytosolic activity, good cytocompatibility and strong antimicrobial ability, which laid a theoretical foundation for the construction of a new PLA/SF composites antimicrobial fiber membrane.
抗菌伤口敷料可以通过防止细菌感染来帮助伤口愈合。这在电纺敷料中尤其如此，电纺敷料具有多孔结构，并且可以很容易地负载抗菌药物。在这里，聚乳酸（PLA）、丝素蛋白（SF）和抗菌剂银纳米粒子（Ag NPs）和氧化银（AgO）通过静电纺丝来制备 PLA/SF 复合材料抗菌纳米纤维膜。PLA 中含有 30%SF 的纳米纤维膜表现出水蒸气透过率（WVP）和液体吸收率为 36 g·mm/（m·d·kPa）和 1721%。随着 SF 含量的增加，纳米纤维膜的降解速率和表面亲水性显著增加。纳米纤维膜对铜绿假单胞菌（P. aeruginosa）表现出优异的抗菌活性，抑菌圈达到 18.2mm。所得纳米纤维膜具有高细胞溶质活性、良好的细胞相容性和较强的抗菌能力，为构建新型 PLA/SF 复合材料抗菌纤维膜奠定了理论基础。
