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Anti-nephrin autoantibodies: a paradigm shift in podocytopathies.

作者信息

Cui Zhao, Zhao Ming-Hui

机构信息

Renal Division, Peking University First Hospital, Beijing, China.

Institute of Nephrology, Peking University, Beijing, China.

出版信息

Nat Rev Nephrol. 2024 Oct;20(10):639-640. doi: 10.1038/s41581-024-00873-7.

DOI:10.1038/s41581-024-00873-7
PMID:39080046
Abstract
摘要

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Anti-nephrin autoantibodies: a paradigm shift in podocytopathies.抗肾足细胞蛋白自身抗体：足细胞病的范式转变
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2
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3
Autoantibodies Targeting Nephrin in Podocytopathies.足细胞病中靶向nephrin的自身抗体。
N Engl J Med. 2024 Oct 10;391(14):1365-1366. doi: 10.1056/NEJMc2410840.
4
Kidney Disease and Antinephrin Antibodies.肾脏疾病与抗肾素抗体
N Engl J Med. 2024 Aug 1;391(5):463-467. doi: 10.1056/NEJMe2404974.
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Pre-transplant anti-nephrin antibodies are specific predictors of recurrent diffuse podocytopathy in the kidney allograft.移植前抗肾足突蛋白抗体是同种异体肾移植中复发性弥漫性足细胞病的特异性预测指标。
Kidney Int. 2024 Oct;106(4):749-752. doi: 10.1016/j.kint.2024.07.022. Epub 2024 Aug 9.
6
Nephrinuria and podocytopathies.尿肾蛋白和足细胞病。
Adv Clin Chem. 2022;108:1-36. doi: 10.1016/bs.acc.2021.08.001. Epub 2021 Sep 10.
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New Anti-Nephrin Antibody Mediated Podocyte Injury Model Using a C57BL/6 Mouse Strain.使用C57BL/6小鼠品系建立新的抗肾足细胞蛋白抗体介导的足细胞损伤模型。
Nephron. 2018;138(1):71-87. doi: 10.1159/000479935. Epub 2017 Sep 30.
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Seven novel podocyte autoantibodies were identified to diagnosis a new disease subgroup-autoimmune Podocytopathies.七种新型足细胞自身抗体被鉴定出来，以诊断一种新的疾病亚组——自身免疫性足细胞病。
Clin Immunol. 2021 Nov;232:108869. doi: 10.1016/j.clim.2021.108869. Epub 2021 Sep 30.
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Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes.血栓反应蛋白 1 型结构域包含 7A 定位于裂孔隔膜并稳定完全分化的足细胞的膜动力学。
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Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy.IgG4 糖基化改变促进抗 PLA2R1 相关膜性肾病中凝集素补体途径的激活。
J Clin Invest. 2021 Mar 1;131(5). doi: 10.1172/JCI140453.

引用本文的文献

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Non-invasive Diagnosis of Antinephrin-Associated Podocytopathy.抗肾素相关足细胞病的无创诊断
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The Prevalence and Characteristics of IgA Antibodies to β2-Spectrin and CBX3 in Immunoglobulin A Nephropathy.IgA 肾病中抗β2-血影蛋白和 CBX3 的 IgA 抗体的患病率及特征
Kidney Int Rep. 2025 Mar 3;10(5):1486-1494. doi: 10.1016/j.ekir.2025.02.025. eCollection 2025 May.
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Revolutionizing Autoimmune Kidney Disease Treatment with Chimeric Antigen Receptor-T Cell Therapy.

本文引用的文献

1
Endopeptidase Cleavage of Anti-Glomerular Basement Membrane Antibodies in Severe Kidney Disease: An Open-Label Phase 2a Study.严重肾脏疾病中抗肾小球基底膜抗体的内肽酶切割：一项开放标签 2a 期研究。
J Am Soc Nephrol. 2022 Apr;33(4):829-838. doi: 10.1681/ASN.2021111460. Epub 2022 Mar 8.
2
Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology.在微小病变性肾病中发现针对 Nephrin 的自身抗体支持新的自身免疫病因。
J Am Soc Nephrol. 2022 Jan;33(1):238-252. doi: 10.1681/ASN.2021060794. Epub 2021 Nov 3.
3
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy.
嵌合抗原受体 T 细胞疗法革新自身免疫性肾病治疗
Research (Wash D C). 2025 May 22;8:0712. doi: 10.34133/research.0712. eCollection 2025.
4
Potential and pitfalls of measuring circulating anti-nephrin autoantibodies in glomerular diseases.测量肾小球疾病中循环抗肾足细胞蛋白自身抗体的潜力与陷阱
Clin Kidney J. 2025 Apr 12;18(5):sfaf100. doi: 10.1093/ckj/sfaf100. eCollection 2025 May.
5
Emerging role of Rituximab in adult minimal change disease: a narrative review of clinical evidence, biomarkers and future perspectives.利妥昔单抗在成人微小病变病中的新作用：临床证据、生物标志物及未来展望的叙述性综述
BMC Nephrol. 2025 Mar 26;26(1):152. doi: 10.1186/s12882-025-04086-3.
6
Is There a Diagnostic and Prognostic Role for Anti-Nephrin Autoantibodies in Diabetic Nephropathy?抗肾足细胞蛋白自身抗体在糖尿病肾病中是否具有诊断和预后价值？
Antibodies (Basel). 2025 Mar 12;14(1):25. doi: 10.3390/antib14010025.
7
Antinephrin autoantibodies: rethinking the pathogenesis of minimal change disease.抗肾素自身抗体：重新思考微小病变病的发病机制。
Ren Fail. 2024 Dec;46(2):2434192. doi: 10.1080/0886022X.2024.2434192. Epub 2024 Dec 2.
IgG4 糖基化改变促进抗 PLA2R1 相关膜性肾病中凝集素补体途径的激活。
J Clin Invest. 2021 Mar 1;131(5). doi: 10.1172/JCI140453.
4
Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy.利妥昔单抗或环孢素治疗膜性肾病。
N Engl J Med. 2019 Jul 4;381(1):36-46. doi: 10.1056/NEJMoa1814427.
5
New Anti-Nephrin Antibody Mediated Podocyte Injury Model Using a C57BL/6 Mouse Strain.使用C57BL/6小鼠品系建立新的抗肾足细胞蛋白抗体介导的足细胞损伤模型。
Nephron. 2018;138(1):71-87. doi: 10.1159/000479935. Epub 2017 Sep 30.
6
Clinical Significance of IgM and C3 Glomerular Deposition in Primary Focal Segmental Glomerulosclerosis.原发性局灶节段性肾小球硬化中IgM和C3肾小球沉积的临床意义
Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1582-1589. doi: 10.2215/CJN.01190216. Epub 2016 Jun 23.
7
Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trial.利妥昔单抗治疗儿童起病、复杂、频繁复发型肾病综合征或激素依赖型肾病综合征：一项多中心、双盲、随机、安慰剂对照试验。
Lancet. 2014 Oct 4;384(9950):1273-81. doi: 10.1016/S0140-6736(14)60541-9. Epub 2014 Jun 22.
8
Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.抗肾小球基底膜肾炎中 Goodpasture 自身抗原的分子结构。
N Engl J Med. 2010 Jul 22;363(4):343-54. doi: 10.1056/NEJMoa0910500.
9
M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.M型磷脂酶A2受体作为特发性膜性肾病的靶抗原
N Engl J Med. 2009 Jul 2;361(1):11-21. doi: 10.1056/NEJMoa0810457.