Departments of Otolaryngology, Head and Neck Surgery, University of Tokyo, 7-3-1, Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Department of Otolaryngology, NTT Medical Center Tokyo, Tokyo, Japan.
Int J Clin Oncol. 2024 Oct;29(10):1444-1450. doi: 10.1007/s10147-024-02591-3. Epub 2024 Jul 30.
Sarcopenia is a poor prognostic factor in various diseases. Temporal muscle thickness (TMT) has been reported to be associated with sarcopenia. We investigated the prognostic value of TMT in patients with oral squamous cell carcinoma.
This study included 61 patients with oral squamous cell carcinoma. Two board-certified otolaryngologists measured TMT based on pre-treatment CT. The following sex-specific TMT cut-off values were used in accordance with previous reports: ≤ 6.3 mm in men, and ≤ 5.2 mm in women. We classified patients into normal TMT group and low TMT group according to the cutoff values. The correlation between the TMT measurements of the two readers was tested using the interclass correlation coefficient (ICC). Cox regression models were used to verify the association between TMT and prognostic factors.
The low TMT group had a significantly lower BMI than the normal TMT group. Patients with low TMT at baseline had a significantly higher risk of death than those with normal TMT (hazard ratio 4.51; 95% confidence interval [CI] 1.49-13.61; p = 0.0076). There were no significant differences in disease-specific survival between the two groups. The correlation between the two evaluators' TMT measurements was excellent (ICC 0.988, 95% CI 0.981-0.933).
Sex-specific TMT was associated with overall survival in patients with oral squamous cell carcinoma. TMT is easy to assess and its measurement is consistent between evaluators.
肌肉减少症是多种疾病的不良预后因素。有研究报道，颞肌厚度（TMT）与肌肉减少症相关。我们研究了 TMT 对口腔鳞状细胞癌患者的预后价值。
本研究纳入了 61 例口腔鳞状细胞癌患者。两位经过认证的耳鼻喉科医生根据治疗前 CT 测量 TMT。根据既往研究报道，采用以下性别特异性 TMT 截断值：男性 TMT 截断值≤6.3mm，女性 TMT 截断值≤5.2mm。我们根据截断值将患者分为 TMT 正常组和 TMT 低组。采用组内相关系数（ICC）检验两位观察者 TMT 测量值的相关性。采用 Cox 回归模型验证 TMT 与预后因素的关系。
TMT 低组的 BMI 显著低于 TMT 正常组。基线 TMT 低的患者死亡风险显著高于 TMT 正常的患者（风险比 4.51；95%置信区间 [CI] 1.49-13.61；p=0.0076）。两组间疾病特异性生存率无显著差异。两位评估者的 TMT 测量值相关性极好（ICC 0.988，95%CI 0.981-0.933）。
性别特异性 TMT 与口腔鳞状细胞癌患者的总生存率相关。TMT 易于评估，评估者间测量值一致。
