School of Clinical Medicine, Peking University Health Science Center, Beijing, 100191, China.
Department of Dermatology and Venereology, Hair Medical Research Center, Beijing Jishuitan Hospital, Capital Medical University, No. 31 of Xinjiekou East Street, Xicheng District, Beijing, 100035, China.
Arch Dermatol Res. 2024 Jul 30;316(8):496. doi: 10.1007/s00403-024-03229-0.
The TEC (tyrosine kinase expressed in hepatocellular carcinoma) family kinases, an important class of protein kinases, play key roles in cell signaling and immune regulation. In this review, the association between the pathogenesis of alopecia areata and the structure and regulatory mechanisms of TEC family kinases in normal physiological processes, is explored. Furthermore, the potential clinical applications of TEC kinases and their inhibitors are highlighted by summarizing current insights into their mechanisms of action, clinical applications, and recent advancements in TEC kinase inhibitor research.
TEC（肝癌细胞中表达的酪氨酸激酶）家族激酶是一类重要的蛋白激酶，在细胞信号转导和免疫调节中发挥关键作用。本综述探讨了斑秃发病机制与 TEC 家族激酶在正常生理过程中的结构和调节机制之间的关联。此外，通过总结 TEC 激酶及其抑制剂的作用机制、临床应用以及最近在 TEC 激酶抑制剂研究方面的进展，强调了 TEC 激酶及其抑制剂的潜在临床应用。
