Tolman E L, Rosenthale M E, Capetola R J, McGuire J L
Clin Rheum Dis. 1984 Aug;10(2):353-68.
Suprofen is a potent, peripherally-acting, non-narcotic analgesic agent. The mechanism of action of the compound involves inhibition of prostaglandin biosynthesis and, perhaps, direct antagonism of the peripheral, pain inducing actions of prostaglandins, bradykinin and other pain mediators. Suprofen at a dose of 200 mg appears to be equal or greater in efficacy as an analgesic modality than those of ibuprofen, propoxyphene, naproxen and diflunisal or a combination of 650 mg aspirin plus 60 mg codeine. Its clinical utility has been amply demonstrated in the treatment of a number of types of pain including general and orthopedic surgery, episiotomy, post-partum pain, dysmenorrhea, dental pain and musculoskeletal disorders. Suprofen represents a new class of orally effective nonnarcotic analgesics with potential for effective clinical use in the treatment of pain.
舒洛芬是一种强效的、作用于外周的非麻醉性镇痛药。该化合物的作用机制包括抑制前列腺素生物合成，或许还包括直接拮抗前列腺素、缓激肽及其他疼痛介质在外周的致痛作用。200毫克剂量的舒洛芬作为一种镇痛方式，其疗效似乎等同于或优于布洛芬、丙氧芬、萘普生和二氟尼柳，或等同于650毫克阿司匹林加60毫克可待因的组合。其临床效用已在多种疼痛治疗中得到充分证明，包括普通外科手术和矫形外科手术、会阴切开术、产后疼痛、痛经、牙痛和肌肉骨骼疾病。舒洛芬代表了一类新型口服有效的非麻醉性镇痛药，具有有效治疗疼痛的临床应用潜力。
