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肝移植治疗不可切除的转移性实性假乳头状胰腺肿瘤

Unresectable Metastatic Solid Pseudopapillary Pancreatic Neoplasm Treated With Liver Transplantation.

作者信息

Pace Jordan L, Hopstone Michelle D, Conti Peter S, Tom Chloe, Mohamed Passant, Gong Yuna, Karne Vidyadhari, Genyk Yuri, Kaur Navpreet, Kahn Jeffrey A

机构信息

California University of Science and Medicine, Colton, CA.

Department of Radiology, Keck School of Medicine of University of Southern California, Los Angeles, CA.

出版信息

ACG Case Rep J. 2024 Jul 27;11(8):e01432. doi: 10.14309/crj.0000000000001432. eCollection 2024 Aug.

Abstract

We present a 49-year-old woman requiring living donor liver transplantation after liver metastasis from a pancreatic solid pseudopapillary tumor. After identifying a pancreatic mass and liver lesions, she underwent extensive surgical resection. Pathology revealed a solid pseudopapillary neoplasm of the head and body of the pancreas, extending into the peripancreatic soft tissues and confirmed to have spread to the liver. Subsequently, she underwent adjuvant chemotherapy and radiofrequency ablations of the new liver lesions. Despite immunotherapy and chemotherapy, there was a progression of the lesions. With interval growth of liver lesions, without evidence of extrahepatic disease, she underwent living donor liver transplantation.

摘要

我们报告了一名49岁女性,因胰腺实性假乳头状瘤肝转移而需要进行活体肝移植。在发现胰腺肿块和肝脏病变后,她接受了广泛的手术切除。病理显示胰腺头部和体部实性假乳头状肿瘤,延伸至胰腺周围软组织,并证实已扩散至肝脏。随后,她接受了辅助化疗和对新出现的肝脏病变进行射频消融。尽管进行了免疫治疗和化疗,病变仍有进展。随着肝脏病变的间歇性生长,且无肝外疾病证据,她接受了活体肝移植。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4cc5/11286244/13c66787fd33/ac9-11-e01432-g001.jpg

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