Pavia D, Agnew J E, Glassman J M, Sutton P P, Lopez-Vidriero M T, Soyka J P, Clarke S W
Eur J Respir Dis. 1985 Sep;67(3):177-84.
We carried out a randomised, double-blind, two-period crossover study in 15 stable, chronic bronchitics to ascertain the effect on tracheobronchial clearance (TBC) of 1 week's treatment with iodopropylidene glycerol (IPG-Organidin), two tablets four times daily compared to matched placebo. TBC was measured by radioaerosol technique. The drug did not significantly alter TBC in the group as a whole but did significantly enhance TBC in 6 patients who expectorated during both placebo and IPG 6-h observation periods. In 4 patients who did not expectorate in either period no change in TBC occurred. In 10 patients who expectorated in either one or both observation periods, a significant positive correlation was found between an index of the patients' sputum produced and improvement in TBC following IPG treatment. IPG can be an effective expectorant in patients with mucus hypersecretion and particularly so in patients with copious sputum production.
我们对15名病情稳定的慢性支气管炎患者进行了一项随机、双盲、两阶段交叉研究，以确定与匹配的安慰剂相比，每日四次、每次两片服用碘丙炔醇甘油（IPG-Organidin）治疗1周对气管支气管清除率（TBC）的影响。TBC通过放射性气溶胶技术测量。总体而言，该药物并未显著改变TBC，但在安慰剂和IPG 6小时观察期内均有咳痰的6名患者中，TBC确实显著提高。在两个观察期内均未咳痰的4名患者中，TBC没有变化。在一个或两个观察期内有咳痰的10名患者中，发现患者痰液生成指数与IPG治疗后TBC的改善之间存在显著正相关。IPG对黏液分泌过多的患者可能是一种有效的祛痰剂，对痰液大量生成的患者尤其如此。
