Hu Xianwen, Zhao Wei, Li Fangming, Wang Pan, Cai Jiong
Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Front Med (Lausanne). 2024 Jul 16;11:1437597. doi: 10.3389/fmed.2024.1437597. eCollection 2024.
Pulmonary mixed squamous cell and glandular papilloma (MSGP) is a rare benign lung tumor with both squamous and glandular epithelial components. Reports on primary lung MSGP are few, and the aim of this study is to describe the imaging, including computed tomography (CT) and positron emission tomography (PET) findings, and histopathological characteristics of a case of MSGP in our hospital. A 53-year-old woman with no smoking history who underwent a chest CT scan revealed a nodule in the upper lobe of the left lung. The solid nodule showed no lobulation or spiculation but demonstrated significant enhancement on contrast-enhanced CT and increased fluorine-18 fluorodeoxyglucose (F-FDG) uptake on PET. Moreover, a literature review identified 19 cases of lung MSGPs involving imaging findings, including CT and/or PET imaging. Except for one patient with a ground glass nodule, the rest were solid and ranged in size from 0.7 to 8.2 cm, which can present as a mildly to significantly increased F-FDG uptake on PET. MSGP is a rare benign tumor entity, and understanding its imaging findings and pathological immunohistochemical characteristics will help to improve the accurate diagnosis of MSGP so as to avoid unnecessary lobectomy and mediastinal lymph node dissection.
肺混合性鳞状细胞和腺性乳头状瘤（MSGP）是一种罕见的良性肺肿瘤，具有鳞状和腺上皮成分。原发性肺MSGP的报道较少，本研究的目的是描述我院1例MSGP的影像学表现，包括计算机断层扫描（CT）和正电子发射断层扫描（PET）结果，以及组织病理学特征。一名53岁无吸烟史的女性接受胸部CT扫描时发现左肺上叶有一个结节。实性结节无分叶或毛刺，但在增强CT上有明显强化，在PET上氟-18氟脱氧葡萄糖（F-FDG）摄取增加。此外，文献回顾确定了19例涉及影像学表现的肺MSGP病例，包括CT和/或PET成像。除1例为磨玻璃结节外，其余均为实性，大小从0.7至8.2 cm不等，在PET上可表现为F-FDG摄取轻度至显著增加。MSGP是一种罕见的良性肿瘤实体，了解其影像学表现和病理免疫组化特征将有助于提高MSGP的准确诊断，从而避免不必要的肺叶切除术和纵隔淋巴结清扫术。
