Smolle J
Dermatologica. 1985;171(5):316-20. doi: 10.1159/000249444.
We investigated the distribution of T-zone histiocytes by immunohistochemical demonstration of S-100 protein in granulomatous skin diseases (granuloma annulare, 8 cases; necrobiosis lipoidica, rheumatoid nodule, sarcoidosis, lupus vulgaris, and foreign-body granuloma; 5 cases each). T-zone histiocytes were regularly found in the lymphohistiocytic mantle, but also occasionally between epitheloid cells. Our results show that, besides the monocyte-macrophage system, T-zone histiocytes consistently contribute to the formation of cutaneous granulomas. These findings may indicate a role of delayed-type hypersensitivity.
我们通过免疫组化检测S-100蛋白，研究了肉芽肿性皮肤病（环状肉芽肿8例；类脂质渐进性坏死、类风湿结节、结节病、寻常狼疮和异物肉芽肿各5例）中T区组织细胞的分布情况。T区组织细胞在淋巴细胞-组织细胞套膜中常有发现，但偶尔也可见于上皮样细胞之间。我们的结果表明，除单核细胞-巨噬细胞系统外，T区组织细胞始终参与皮肤肉芽肿的形成。这些发现可能提示迟发型超敏反应的作用。
