Tom Stephanie K, Kalra Kanika, Perdoncin Emily, Tully Andy, Devireddy Chandan M, Inci Errol, Greenbaum Adam, Grubb Kendra J
Division of Cardiothoracic Surgery, Department of Surgery, Emory University School of Medicine Atlanta, GA, US.
Division of Cardiology, Department of Medicine, Emory University School of Medicine Atlanta, GA, US.
Interv Cardiol. 2024 Jul 3;19:e10. doi: 10.15420/icr.2021.29. eCollection 2024.
Mitral regurgitation is the most common valvular disease in the developed world, with approximately 24.2 million people being affected worldwide and a higher prevalence in older age groups. Surgical correction of degenerative mitral regurgitation is the standard of care and can restore cardiac function and provide a lasting result, especially when the mitral valve can be repaired. Secondary mitral regurgitation, or functional mitral regurgitation (FMR), describes atrial or ventricular factors leading to poor coaptation of an otherwise non-diseased valve. For FMR, traditional surgery has not produced the same level of benefit. Transcatheter mitral repair and replacement techniques that mimic surgical correction are under investigation. Transcatheter edge-to-edge repair is the only approved catheter-based therapy for FMR in the US. Here, the transcatheter treatment options for FMR are reviewed.
二尖瓣反流是发达国家最常见的瓣膜疾病，全球约有2420万人受其影响，且在老年人群中的患病率更高。退行性二尖瓣反流的外科矫正术是治疗的标准方法，能够恢复心脏功能并产生持久疗效，尤其是在二尖瓣能够修复的情况下。继发性二尖瓣反流，即功能性二尖瓣反流（FMR），是指导致原本无病变瓣膜对合不良的心房或心室因素。对于FMR，传统手术并未产生相同程度的益处。模拟外科矫正的经导管二尖瓣修复和置换技术正在研究中。经导管缘对缘修复术是美国唯一获批的用于FMR的基于导管的治疗方法。在此，对FMR的经导管治疗选择进行综述。
