Taylor Kenneth A, Carroll Megan K, Short Sarah A, Celestin Bettia E, Gilbertson Adam, Olivier Christoph B, Haddad Francois, Cauwenberghs Nicholas
Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, United States.
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, United States.
Front Sports Act Living. 2024 Jul 15;6:1393332. doi: 10.3389/fspor.2024.1393332. eCollection 2024.
Physical performance tests are predictive of mortality and may screen for certain health conditions (e.g., sarcopenia); however, their diagnostic and/or prognostic value has primarily been studied in age-limited or disease-specific cohorts. Our objective was to identify the most salient characteristics associated with three lower quarter balance and strength tests in a cohort of community-dwelling adults.
We applied a stacked elastic net approach on detailed data on sociodemographic, health and health-related behaviors, and biomarker data from the first visit of the Project Baseline Health Study ( = 2,502) to determine which variables were most associated with three physical performance measures: single-legged balance test (SLBT), sitting-rising test (SRT), and 30-second chair-stand test (30CST). Analyses were stratified by age (<65 and ≥65).
Female sex, Black or African American race, lower educational attainment, and health conditions such as non-alcoholic fatty liver disease and cardiovascular conditions (e.g., hypertension) were consistently associated with worse performance across all three tests. Several other health conditions were associated with either better or worse test performance, depending on age group and test. C-reactive protein was the only laboratory value associated with performance across age and test groups with some consistency.
Our results highlighted previously identified and several novel salient factors associated with performance on the SLBT, SRT, and 30CST. These tests could represent affordable, noninvasive biomarkers of prevalent and/or future disease in adult individuals; future research should validate these findings.
ClinicalTrials.gov, identifier NCT03154346, registered on May 15, 2017.
身体机能测试可预测死亡率，并可筛查某些健康状况（如肌肉减少症）；然而，其诊断和/或预后价值主要在年龄受限或特定疾病队列中进行了研究。我们的目的是在一组社区居住的成年人中确定与三项下肢平衡和力量测试相关的最显著特征。
我们对项目基线健康研究首次访视（n = 2502）的社会人口统计学、健康及与健康相关行为的详细数据以及生物标志物数据应用了堆叠弹性网络方法，以确定哪些变量与三项身体机能指标最相关：单腿平衡测试（SLBT）、坐立测试（SRT）和30秒坐椅起立测试（(30CST)）。分析按年龄（<65岁和≥65岁）分层。
女性、黑人或非裔美国人、较低的教育程度以及非酒精性脂肪性肝病和心血管疾病（如高血压）等健康状况在所有三项测试中均始终与较差的表现相关。根据年龄组和测试的不同，其他几种健康状况与测试表现的好坏相关。C反应蛋白是唯一在年龄和测试组中表现与测试表现有一定一致性关联的实验室指标。
我们的结果突出了先前确定的以及与SLBT、SRT和(30CST)表现相关的几个新的显著因素。这些测试可能代表了成年个体中普遍存在的和/或未来疾病的经济实惠、非侵入性生物标志物；未来的研究应验证这些发现。
ClinicalTrials.gov，标识符NCT03154346，于2017年5月15日注册。
