Keskin Doğukan Mustafa, Kocaoğlu Mehmet, Yıldırım Alper, Sayan Ender, Avcı Muhammed Yusuf Ozan
Department of Pediatrics, Ministry of Health Konya Dr Ali Kemal Belviranlı Obstetrics and Gynecology Hospital, Konya, Turkey.
Pediatr Allergy Immunol Pulmonol. 2025 Mar;38(1):29-31. doi: 10.1089/ped.2024.0035. Epub 2024 Jul 31.
Tranexamic acid (TXA) is a medication used to treat or prevent excessive blood loss due to certain medical conditions. It has a low side effect profile and is safe to administer in most instances. Anaphylaxis cases due to intravenous TXA have been reported in the literature. We report the first pediatric case of anaphylaxis due to the use of nebulized TXA. A 2-year-old boy with cerebral palsy, epilepsy, and tracheostomy was hospitalized with pneumonia. On the fourth day of hospitalization, the patient started bleeding from the trachea. Nebulized TXA was started to reduce tracheal bleeding. Anaphylaxis developed 5 min after administration of nebulized TXA. Subsequently, the patient was successfully treated with adrenaline, intravenous fluids, antihistamines, and steroids. Nebulized TXA is increasingly used off-label. Although it has a safe profile, side effects such as anaphylaxis may occur rarely. It is essential to recognize the symptoms of anaphylaxis when using nebulized TXA.
氨甲环酸（TXA）是一种用于治疗或预防因某些医疗状况导致的过度失血的药物。它的副作用较小，在大多数情况下使用是安全的。文献中已报道过静脉注射TXA引起过敏反应的病例。我们报告了首例因使用雾化TXA导致过敏反应的儿科病例。一名患有脑瘫、癫痫和气管造口术的2岁男孩因肺炎住院。住院第四天，患者开始出现气管出血。开始使用雾化TXA以减少气管出血。雾化TXA给药5分钟后发生过敏反应。随后，患者通过肾上腺素、静脉输液、抗组胺药和类固醇成功治愈。雾化TXA越来越多地被用于非标签用途。尽管它安全性良好，但过敏反应等副作用可能很少发生。使用雾化TXA时识别过敏反应的症状至关重要。
