[Sonographic diagnosis of holoprosencephaly in the 2d trimester].

Data on the sonographic diagnosis of holoprosencephaly in the second trimester are presented. Polyhydramnions was detected during outside ultrasound screening, and the lacking midline echo in association with hypotelorism and central face clefting allowed early diagnosis. The autopsy of the fetus confirmed the prenatal diagnosis, the parents subsequently had genetic counseling. The recurrence risk of holoprosencephaly depends on the specific etiology. Special ultrasound examination should be offered in subsequent pregnancies.