Eye Research Center, Khatam-al-Anbia Eye Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Ocular Oncology Service, Department of Ophthalmology and Visual Sciences, University of Toronto, Toronto, Canada.
J Int Med Res. 2024 Jul;52(7):3000605241263236. doi: 10.1177/03000605241263236.
To evaluate longitudinal changes in peripapillary vessel density (VD) following coronavirus disease 2019 (COVID-19) using optical coherence tomography angiography.
As part of a prospective longitudinal observational study, we studied healthy individuals with a history of mild COVID-19 confirmed via real-time polymerase chain reaction. After recovery, we used the Optovue RTVue XR Avanti machine to perform optic nerve head (ONH) imaging. We also assessed the VD of all vessels and of small vessels in the disc and the radial peripapillary capillary (RPC) network at 1 and 3 months post-recovery.
We included 17 patients (34 eyes; mean age: 36.9 ± 10.2 years, range: 24-62 years) who had recovered from COVID-19. No changes were observed in the ONH parameters. However, there was a noticeable trend of increased small vessel VD values in the RPC. These increases were significant for the peripapillary whole, superior hemifield, inferior-temporal, temporal-superior, and superior-temporal small vessels. Moreover, the evaluation of all vessel VD values in the RPC revealed a significant decrease in the inside disc and a significant increase in a grid-based inferior region.
COVID-19 may affect VD of the RPC in the ONH, and should be considered in ONH evaluations.
利用光相干断层扫描血管造影术评估新冠肺炎（COVID-19）后视盘周围血管密度（VD）的纵向变化。
作为一项前瞻性纵向观察性研究的一部分，我们研究了经实时聚合酶链反应（PCR）确诊为轻度 COVID-19 且有病史的健康个体。康复后，我们使用 Optovue RTVue XR Avanti 机器对视神经头（ONH）成像。我们还在康复后 1 个月和 3 个月评估了所有血管和盘内小血管以及放射状视盘周围毛细血管（RPC）网络的 VD。
我们纳入了 17 名（34 只眼；平均年龄：36.9±10.2 岁，范围：24-62 岁）从 COVID-19 中康复的患者。ONH 参数无变化。然而，RPC 中小血管 VD 值的增加趋势明显。这些增加对视盘周围的整体、上半视野、下颞、颞上和上颞小血管有统计学意义。此外，对 RPC 中所有血管 VD 值的评估显示，盘内的血管密度显著降低，网格状下方区域的血管密度显著增加。
COVID-19 可能会影响 ONH 中 RPC 的 VD，在 ONH 评估中应予以考虑。
