High PLK3 levels are linked with less tumor invasion, lower FIGO stage and better prognosis of endometrial cancer.

To evaluate correlations of tumor PLK3 with clinical features and prognosis of resectable endometrial cancer (EC) patients. Tumor tissues from 200 EC patients receiving surgical resections and adjacent tissues from 50 of them were collected for PLK3 determination using immunohistochemistry. Tumor PLK3 negatively linked with myometrial invasion ≥50%, lymphovascular invasion, stromal cervical invasion, and International Federation of Gynecology and Obstetrics stage (all p < 0.050). High tumor PLK3 independently related to longer disease-free survival (DFS) (p = 0.044) and overall survival (OS) (p = 0.049). Its prognostic value was also validated by time-dependent receiver operating characteristic analyses (area under curve at most timepoints was >0.700). Tumor PLK3 potentially reflects prolonged DFS and OS in EC patients undergoing surgical resections.