Department of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Itabashi, Tokyo, Japan.
Jpn J Ophthalmol. 2024 Sep;68(5):429-442. doi: 10.1007/s10384-024-01083-1. Epub 2024 Jul 31.
Endothelial transplantation has recently been accepted worldwide, in the long history of corneal transplantation. The introduction of endothelial keratoplasty (Descemet stripping automated endothelial keratoplasty and Descemet membrane endothelial keratoplasty) has enabled us to expand the surgical indications owing to the low incidence of rejection and quick recovery of visual function. New technologies have been developed to ensure stable postoperative outcomes with a shorter learning curve, such as transplantation using cultured human endothelial cells and induced pluripotent stem cells (iPS) or new devices such as artificial endothelium. This review discusses the history and characteristics of corneal transplantation alongside new treatment options that may offer hope for patients with endothelial disease in the future.
内皮移植术在角膜移植的漫长历史中最近被全世界所接受。内皮角膜移植术（撕囊自动化角膜内皮移植术和 Descemet 膜内皮角膜移植术）的引入使我们能够扩大手术适应证，因为其排斥反应发生率低，视觉功能恢复迅速。新技术的发展确保了更短的学习曲线和更稳定的术后效果，例如使用培养的人内皮细胞和诱导多能干细胞（iPS）进行移植，或者使用人工内皮等新设备。本文讨论了角膜移植的历史和特点，以及未来可能为内皮疾病患者带来希望的新治疗选择。
